C. Ma

The m6A Reader ECT1 Mediates Seed Germination via the DAG2-ECT1-PHYB Regulatory Cascade in Arabidopsis

This study identifies ECT1 as an m6A reader protein that promotes seed germination in Arabidopsis through a DAG2-ECT1-PHYB regulatory cascade involving transcriptional and post-transcriptional control.

Epithelial NSD2 maintains FMOs-mediated taurine biosynthesis to prevent intestinal barrier disruption

The paper shows NSD2 maintains taurine biosynthesis via FMOs in intestinal epithelial cells, preventing barrier disruption in IBD.

Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium

The paper traces the evolutionary changes in TRPM2 channel activation mechanisms across species, identifying key stages in the transition from simple to complex ligand binding and calcium gating.

Engineering customized viral receptors for various coronaviruses

This paper develops a method to engineer customized viral receptors (CVRs) for various coronaviruses, enabling infection models for viruses lacking known receptors.

Sarbecovirus RBD indels and specific residues dictating ACE2 multi-species adaptiveness

This study identifies RBM indel types in sarbecoviruses and their impact on ACE2 receptor usage across species, revealing how specific residues and structural features influence tropism and adaptiveness.

Architecture of intact mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis

This study reveals the in-situ architecture of the mammalian pyruvate dehydrogenase complex using cryo-electron tomography, showing dynamic interactions and variable peripheral compositions.

The Gut Microbiome Controls Liver Tumors via the Vagus Nerve

This study shows that gut microbiota influence liver tumor growth and behavior through the vagus nerve, with cholinergic signaling and CD8+ T cells playing key roles.

DNA sensor ABCF1 phase separates with cccDNA to inhibit HBV replication

This study identifies ABCF1 as a host protein that interacts with cccDNA, forming phase-separated condensates to suppress HBV replication through innate immune activation and transcription inhibition.

Epithelial organoid supports resident memory CD8 T cell differentiation

This paper develops a murine vaginal epithelial organoid system that supports CD8 T cell differentiation into resident memory T cells in vitro, showing phenotypic and transcriptional similarity to in vivo TRM.

Platelet-specific TGFβ1 deficiency aggravates atherosclerosis, vascular inflammation, and hypercholesterolemia in mice

Multilevel regulation of NF-kappa B signaling by NSD2 suppresses Kras-driven pancreatic tumorigenesis

This study shows NSD2 acts as a tumor suppressor in Kras-driven pancreatic cancer by regulating NF-kappa B signaling through multiple mechanisms.

AI in Paleontology

This paper reviews AI applications in paleontology, highlighting a gap between paleontological AI and mainstream AI studies, and discusses future directions for integrating AI into paleontological research.

On-Demand Expansion Fluorescence and Photoacoustic Microscopy (ExFLPAM)

This paper introduces ExFLPAM, a method that expands the capabilities of expansion microscopy by enabling on-demand fluorescent labeling and non-fluorescent imaging in live cells and tissues.

Synergistic effects of multiple pesticides on the flight ability of honey bees (Apis cerana F.)

This study shows that combinations of imidacloprid, chlorpyrifos, and glyphosate synergistically reduce flight ability in honey bees, while individual pesticides do not.

Massive expansion of the pig gut virome based on global metagenomic mining

This study establishes the Pig Virome Database (PVD) by mining global metagenomic data, revealing extensive viral diversity and functional potential in the pig gut.

Pan-cancer analysis reveals tumor microbiome associations with host molecular aberrations

This study identifies associations between tumor microbiomes and host molecular aberrations across 32 cancer types using multi-omics data from TCGA.

A proximity-dependent biotinylation map of cytosol-facing organelle outer membrane proteome in living Arabidopsis cells

The paper develops an OM proximity labeling system to map the proteome of cytosol-facing outer membranes in Arabidopsis cells and identifies potential receptors for protein translocation and organelle communication.

Mass-immigration shapes the antibiotic resistome of wastewater treatment plants

The paper monitors antibiotic resistance genes in wastewater treatment plants and finds that mass-immigration of bacteria and ARGs from upstream units shapes ARG communities, with stochastic processes dominating their assembly.

Design, evaluation and implementation of synthetic isopentyldiol pathways in Escherichia coli

The paper designs and evaluates synthetic isopentyldiol pathways in E. coli, finding that a computationally designed pathway produces IPDO at 2.2 mg/L from glucose.

Assembly and operation of a cooling stage to immobilize C. elegans on their culture plates

This paper describes the construction and use of a cooling stage to immobilize C. elegans on culture plates for high-resolution imaging.

Identification of a key genetic factor governing arabinan utilization in the gut microbiome suggests a novel therapeutic target for constipation

The paper identifies the abfA cluster as a key genetic factor for arabinan utilization in gut microbiota, showing its therapeutic potential for constipation through improved gut motility and metabolite production.

Regulation of interstitial fluid flow along adventitia of vasculature by heartbeat and respiration

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

Perturbation of mitochondrial Ca2+ homeostasis activates cross-compartmental proteostatic response in Arabidopsis

This study shows that disrupting mitochondrial Ca2+ homeostasis in Arabidopsis leads to misregulated gene expression and proteostatic responses, affecting plant growth and stress resistance.

Broad host tropism of ACE2-using MERS-related coronaviruses and determinants restricting viral recognition

The paper identifies host range determinants of ACE2-using MERS-related coronaviruses by analyzing receptor recognition across mammals.

Maf Family Transcription Factors are Required for Nutrient Uptake in the Neonatal Gut

This study identifies MafB and cMaf as transcription factors essential for neonatal gut nutrient uptake, showing their role in endo-lysosomal programs and metabolic pathway changes.

GWAS identifies candidate genes controlling adventitious rooting in Populus trichocarpa

This study uses GWAS to identify 277 candidate genes associated with adventitious rooting in Populus trichocarpa, highlighting roles in hormone signaling, cell division, and reactive oxygen species.

GWAS identifies candidate regulators of in planta regeneration in Populus trichocarpa

This study uses GWAS to identify candidate genes regulating in planta regeneration in Populus trichocarpa, finding over 200 genes involved in cell adhesion, stress signaling, and hormone pathways.

Integration of single-cell RNA and protein data identifies novel clinically-relevant lymphocyte phenotypes in breast cancers

The paper integrates single-cell RNA and protein data from breast cancer samples to identify novel lymphocyte phenotypes and their clinical relevance.

Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis

This study identifies how Rabphilin 3A binds the N-peptide of SNAP-25 to enhance SNARE complex assembly, facilitating vesicle exocytosis.

Comparative genomics of orobanchaceous species with different parasitic lifestyles reveals the origin and stepwise evolution of plant parasitism

This study compares genomes of orobanchaceous plants with different parasitic lifestyles to trace the evolutionary steps of plant parasitism.