D. Wood

Loss of FBXO11 function establishes a stem cell program in acute myeloid leukemia through dysregulation of the mitochondrial LONP1

This study identifies FBXO11 loss as a driver of AML by promoting a stem cell program through mitochondrial dysregulation.

Genetic assimilation of ancestral plasticity during parallel adaptation

The paper investigates how ancestral plasticity contributes to adaptive evolution in two independently evolved lineages of zinc-tolerant Silene uniflora, finding that genetic assimilation of ancestral plasticity explains a third of constitutive differences between ecotypes.

Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma

This study shows that stromal collagen structures in pancreatic ductal adenocarcinoma promote early dissemination from pre-malignant lesions and ongoing invasion, suggesting FAK inhibition or stroma normalization could limit metastasis.

Phylogenomics supports a Cenozoic rediversification of the "living fossil" Isoetes

The paper uses genomic data and fossil records to date the origin of extant Isoetes species, finding their diversification occurred in the mid-Paleogene, not the Triassic.

Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in 3-Dimensional Models

This study develops 3D collagen microtissues with fibroblast coatings to sustain primary human hepatocyte functions for 6+ weeks, outperforming spheroids and macrogels in hepatic function and drug response.

SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis

This study shows SEMA4C promotes osteosarcoma growth and metastasis, with its inhibition reducing tumor progression and suggesting clinical potential.