Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
The paper uses simulations to show that CD45 oligomerization and close-cell contacts reduce the time for its surface evacuation, which is critical for T cell receptor triggering.
bioRxiv · Sep 29, 2021Biophysics
M. Bovyn, B. Reddy, S. Gross, J. Allard
This study shows that motor organization on cellular cargos affects microtubule binding and transport efficiency, with freely-diffusing motors optimizing both.
bioRxiv · Dec 20, 2020 · PreprintCell Biology
L. Clemens, M. Kutuzov, K. V. Bayer, J. Goyette, J. Allard, O. Dushek
This study measures the molecular reach of PD-1 tethered SHP-1 complexes and shows how tethering affects substrate accessibility and enzyme activity.
bioRxiv · Sep 4, 2020Biophysics
J. Goyette, D. Depoil, Z. Yang, S. A. Isaacson, J. Allard, P. A. van der Merwe, K. Gaus, M. Dustin, O. Dushek
The paper shows that ZAP70 unbinding from TCR is regulated by kinetic avidity, allowing both signal fidelity and reversibility in T cell responses.
bioRxiv · Feb 12, 2020 · PreprintImmunology
F. Paoletti, A. El-Sagheer, J. Allard, T. Brown, O. Dushek, F. Esashi
This study shows RAD51 binds faster to flexible single-stranded DNA than rigid DNA or double-stranded DNA, suggesting DNA flexibility aids in homologous recombination.
bioRxiv · Jun 25, 2019Biochemistry
Y. Zhang, L. Clemens, J. Goyette, J. Allard, O. Dushek, S. A. Isaacson
The paper studies how molecular reach and diffusivity affect reaction efficacy in membrane-confined systems, showing that increasing reach can enhance or reduce efficacy depending on diffusion rates.
bioRxiv · Apr 7, 2019Biophysics
K. Liu, B. Chu, J. Newby, E. Read, J. Lowengrub, J. Allard
This paper simulates cell-cell contact formation to show that thin-layer fluid dynamics slow receptor-ligand interactions, requiring active forces or high permeability to overcome.
bioRxiv · Jul 12, 2018Biophysics