H. Ren

MixtureFinder: Estimating DNA mixture models for phylogenetic analyses

MixtureFinder estimates optimal DNA mixture models for phylogenetic analyses by selecting the best number of classes for Q matrices in DNA sequence evolution.

Human ANP32A/B are SUMOylated and utilized by avian influenza virus NS2 protein to overcome species-specific restriction

This study shows that human ANP32A/B are SUMOylated, enabling avian influenza virus NS2 to enhance polymerase activity and overcome species-specific restrictions.

Locally released somatostatin triggers cAMP and Ca2+ signaling in primary cilia to modulate pancreatic β-cell function

This study shows that somatostatin acting on primary cilia of pancreatic β-cells modulates cAMP and Ca2+ signaling, affecting β-cell function and linking cilia length to type-2 diabetes.

Hepatic Macrophage Migration Inhibitory Factor Promotes Pancreatic Cancer Liver Metastasis in NAFLD

This study shows that hepatic MIF promotes PDAC liver metastasis in NAFLD by enhancing cancer stemness and immune suppression through the MIF-CD44 axis.

PFKP regulates AXL-MET oncogenic and metabolic pathways in lung cancer

This study shows PFKP promotes lung cancer progression by interacting with the AXL-MET pathway, beyond its metabolic role in glycolysis.

Cell circuits underlying nanomaterial specific respiratory toxicology

This study uses single-cell RNA-sequencing to analyze how different nanomaterials affect lung inflammation in mice, identifying cell type-specific responses and mechanisms.

Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

This study shows capsaicin directly binds KEAP1 and allosterically activates NRF2, reducing ethanol-induced gastric oxidative damage and suggesting its potential as a novel NRF2 agonist for oxidative stress-related diseases.

Non-modular Fatty Acid Synthases Yield Unique Acylation in Ribosomal Peptides

The paper identifies lipoavitides, a novel class of RiPP/fatty acid hybrid lipopeptides with a unique HMP modification, and describes their biosynthetic pathway.

Autoantibodies against eukaryotic translation elongation factor 1 delta (EEF1D) in two patients with autoimmune cerebellar ataxia

This study identifies anti-EEF1D autoantibodies in two patients with autoimmune cerebellar ataxia, suggesting their potential as a biomarker for diagnosis and recurrence prevention.

Bimodality in Ras signaling originates from processivity of the Ras activator SOS without classic kinetic bistability

The paper shows that Ras signaling bimodality arises from SOS processivity, not kinetic bistability, and is controlled by scaffold protein condensation.

Genome mining unveils a class of ribosomal peptides with two amino termini

The paper identifies a new class of ribosomal peptides, daptides, with two amino termini, discovered through genome mining and characterized experimentally.

PRL1 negatively regulates Rho GTPase-independent and -dependent signaling pathways maintaining actin microfilament dynamic for pavement cell morphogenesis

This study identifies PRL1 as a regulator of actin microfilament dynamics in Arabidopsis pavement cells through both Rho GTPase-dependent and -independent pathways.

IL-15 enhances functional properties and responses of CD28-negative CD4+ cytotoxic T cells expanded in Systemic lupus erythematosus

The paper identifies CD4+CD28- cytotoxic T cells in SLE patients and shows IL-15 enhances their expansion and cytotoxic function, with JAK3 inhibition blocking this effect.

Latitude influences stability via stabilizing mechanisms in naturally-assembled forest ecosystems at different spatial grains

The paper examines how latitude affects ecosystem stability in forests across different spatial scales, finding that species asynchrony and stability play key roles, with latitude influencing these mechanisms to counteract species richness effects.

Integrated transcriptome and lineage analyses reveal novel catecholaminergic cardiomyocytes contributing to the cardiac conduction system in murine heart

This study identifies a novel catecholaminergic cardiomyocyte population expressing Dbh that contributes to the murine cardiac conduction system through transcriptomic, genetic, and optogenetic analyses.

TWISTED DWARF1 mediates myosin XI-associated vesicle trafficking required for auxin transport

This study identifies TWD1 as an ER-actin adapter that links myosin XI-K to auxin transport, explaining defects in ABCB biogenesis and plant development.

Cell detoxification of secondary metabolites by P4-ATPase mediated vesicle transport

The paper identifies a P4-ATPase gene in a fungus that mediates detoxification of immunosuppressants via vesicle transport, with cross-species resistance applications in plants and human health.

Global Mutational Sweep of SARS-CoV-2: from Chaos to Order

The paper analyzes SARS-CoV-2 genome sequences to show mutation sweeps driven by emerging variants, which may prolong the pandemic and challenge control efforts.

Camel nanobodies broadly neutralize SARS-CoV-2 variants

The paper isolates two camel nanobodies that broadly neutralize SARS-CoV-2 and its variants, showing therapeutic potential in mice.

Locally-correlated kinetics of post-replication DNA methylation reveals processivity and region-specificity in DNA methylation maintenance

The paper uses mathematical models and stochastic simulations to show that DNA methylation maintenance rates are locally correlated, revealing processivity and region-specificity in methyltransferase activity.

Reassortment Network of Influenza A Virus

This study analyzes the reassortment network of Influenza A Virus using genome-wide data to identify reassortment events and their evolutionary implications.

Cell-to-cell variability in inducible Caspase9-mediated cell death

The paper investigates cell-to-cell variability in iCasp9-mediated cell death and identifies initial iCasp9 expression and XIAP/Caspase3 ratio as key factors, showing that combinatorial drugging can reduce drug resistance.

Biochar alters soil properties, microbial community diversity, and enzyme activities, while decreasing conifer performance

This study evaluates the effects of two biochars on soil properties, microbial communities, and conifer growth in a Christmas tree plantation over three years, finding both positive and negative impacts.

The autophagy initiating kinase ULK1 is required for pancreatic cancer cell growth and survival

This study shows ULK1 is essential for pancreatic cancer cell growth and survival, and ULK1 inhibitors can enhance immunotherapy by increasing MHC Class I expression.

Biphasic Control of Cell Expansion by Auxin Coordinates Etiolated Seedling Development

The paper shows auxin's biphasic control of cell expansion coordinates hypocotyl elongation and apical hook formation in etiolated seedlings.

Role and Dynamics of Vacuolar pH during Cell-in-Cell mediated Death

This study uses pH-sensitive fluorescent protein to track vacuolar pH changes during cell-in-cell mediated death, revealing distinct pH dynamics in entotic and apoptotic death and their implications for cancer treatment.

Viral mimicry of p65/RelA transactivation domain to inhibit NF-κB activation

This paper identifies a viral protein that mimics a host protein to inhibit NF-κB activation, revealing a mechanism of viral immune evasion.

Species packing and the latitudinal gradient in beta-diversity

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

Accurate Diagnosis of Colorectal Cancer Based on Histopathology Images Using Artificial Intelligence

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

Foundation species across a latitudinal gradient in China

The paper identifies candidate foundation species in Chinese forests across a latitudinal gradient and finds they are more common in temperate zones than in tropical or boreal regions.