Author

E. Seitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Approach:deep learning· 2 Research Focus:benchmarking· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Approach:simulation· 1 Organism:virus· 1

Frequent Co-Authors

J. Frank· 3 shared F. Acosta-Reyes· 2 shared P. Schwander· 2 shared S. Maji· 2 shared A. Ourmazd· 1 shared A. T. Bogetti· 1 shared F. J. Acosta-Reyes· 1 shared F. L. Kearns· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiophysics

J. Frank

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Author profile →

3 papers

Recent·Most cited

Geometric machine learning informed by ground truth: Recovery of conformational continuum from single-particle cryo-EM data of biomolecules

E. Seitz, F. J. Acosta-Reyes, S. Maji, P. Schwander, J. Frank

This paper introduces an unsupervised geometric machine learning approach to recover conformational continua from single-particle cryo-EM data using simulated ground-truth datasets, showing improved results over previous methods.

bioRxiv · Jun 18, 2021 · PreprintBiophysics

A glycan gate controls opening of the SARS-CoV-2 spike protein

T. E. Sztain, S.-H. Ahn, A. T. Bogetti, L. Casalino, J. A. Goldsmith, E. Seitz, R. S. McCool, F. L. Kearns, F. Acosta-Reyes, S. Maji, G. Mashayekhi, J. A. McCammon, A. Ourmazd, J. Frank, J. S. McLellan, , R. E. Amaro

This study identifies a glycan gate and key residues that facilitate SARS-CoV-2 spike protein RBD opening through simulations and experimental validation.

bioRxiv · Feb 15, 2021Biophysics

Simulation of cryo-EM ensembles from atomic models of molecules exhibiting continuous conformations

E. Seitz, F. Acosta-Reyes, P. Schwander, J. Frank

This paper simulates cryo-EM ensembles from atomic models of molecules with continuous conformations to test machine learning methods for free energy landscape reconstruction.

bioRxiv · Dec 3, 2019 · PreprintBiophysics