Author

R. S. McCool

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Approach:simulation· 1 Organism:virus· 1

Frequent Co-Authors

A. Ourmazd· 1 shared A. T. Bogetti· 1 shared D. W. Taylor· 1 shared E. Seitz· 1 shared F. Acosta-Reyes· 1 shared F. L. Kearns· 1 shared G. Mashayekhi· 1 shared J. A. Goldsmith· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiophysics

A. Ourmazd

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Structural basis for mismatch surveillance by CRISPR/Cas9

J. P. Bravo, M.-S. Liu, R. S. McCool, K. Jung, K. A. Johnson, D. W. Taylor

This study identifies a linear gRNA:DNA duplex conformation that prevents Cas9 activation in the presence of PAM-distal mismatches, offering insights for improving Cas9 specificity.

bioRxiv · Sep 14, 2021Biochemistry

A glycan gate controls opening of the SARS-CoV-2 spike protein

T. E. Sztain, S.-H. Ahn, A. T. Bogetti, L. Casalino, J. A. Goldsmith, E. Seitz, R. S. McCool, F. L. Kearns, F. Acosta-Reyes, S. Maji, G. Mashayekhi, J. A. McCammon, A. Ourmazd, J. Frank, J. S. McLellan, , R. E. Amaro

This study identifies a glycan gate and key residues that facilitate SARS-CoV-2 spike protein RBD opening through simulations and experimental validation.

bioRxiv · Feb 15, 2021Biophysics