Author

J. A. Goldsmith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Approach:simulation· 1 Organism:virus· 1

Frequent Co-Authors

J. S. McLellan· 3 shared C.-L. Hsieh· 2 shared D. Wrapp· 2 shared N. Wang· 2 shared A. Dzifa· 1 shared A. G.-W. Lee· 1 shared A. M. DiVenere· 1 shared A. Ourmazd· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

J. S. McLellan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BiophysicsbioRxivFeb 15, 2021

A glycan gate controls opening of the SARS-CoV-2 spike protein

T. E. Sztain, S.-H. Ahn, A. T. Bogetti…·R. E. Amaro

This study identifies a glycan gate and key residues that facilitate SARS-CoV-2 spike protein RBD opening through simulations and experimental validation.

DOI 10.1038/s41557-021-00758-3

viruscryo-EM

𝕏 PostBluesky

MicrobiologybioRxivMay 30, 2020

Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes

C.-L. Hsieh, J. A. Goldsmith, J. M. Schaub…·J. S. McLellan

This study designs and characterizes prefusion-stabilized SARS-CoV-2 spike variants to improve protein yield and stability for vaccine and diagnostic development.

DOI 10.1126/science.abd0826

cryo-EMexperimental assay

𝕏 PostBluesky

MicrobiologySciencePeer-reviewedMar 13, 2020

Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation

D. Wrapp, N. Wang, K. S. Corbett…·J. S. McLellan

The paper determines the cryo-EM structure of the 2019-nCoV Spike protein in the prefusion conformation and shows higher ACE2 binding affinity compared to SARS-CoV.

DOI 10.1126/science.abb2507

cryo-EMexperimental assay

𝕏 PostBluesky