S. Maji

KDM6A Regulates Immune Response Genes in Multiple Myeloma

This study shows KDM6A regulates immune response genes in multiple myeloma by activating NLRC5 and CIITA, and its loss reduces MHC expression, which can be reversed by HDAC3 inhibitors.

Leishmania major-induced alteration of host cellular and systemic copper homeostasis drives the fate of infection

This study shows Leishmania major manipulates host copper homeostasis to evade immune responses, while macrophages use copper to kill parasites.

Regulation of apico-basolateral trafficking polarity of homologous Copper-ATPases ATP7A and ATP7B

This study identifies AP-1 isoforms as regulators of apico-basolateral trafficking polarity of ATP7A and ATP7B in polarized epithelia.

Copper-independent lysosomal localization of the Wilson disease protein ATP7B

This study reveals that ATP7B, the Wilson disease protein, has a copper-independent lysosomal localization in hepatocytes and recycles between TGN and TGN-proximal lysosomes for copper transport.

Using spatio-temporal information in weather radar data to detect and track communal bird roosts

This paper develops an AI system to detect and track swallow roosts in weather radar data, improving detection performance with temporal information and reducing human effort.

Redox state and cellular uptake of copper is regulated by the N-terminus of human Copper Transporter-1

The paper shows that the N-terminus of hCTR1 regulates copper uptake by coordinating Cu(I) and facilitating its reduction from Cu(II).

Geometric machine learning informed by ground truth: Recovery of conformational continuum from single-particle cryo-EM data of biomolecules

This paper introduces an unsupervised geometric machine learning approach to recover conformational continua from single-particle cryo-EM data using simulated ground-truth datasets, showing improved results over previous methods.

Decade-long remissions of leukemia sustained by the persistence of activated CD4+ CAR T-cells

This study tracks long-term persistence of CD4+ CAR T-cells in CLL patients, showing their role in sustained remission and clonal stability over 10 years.

A glycan gate controls opening of the SARS-CoV-2 spike protein

This study identifies a glycan gate and key residues that facilitate SARS-CoV-2 spike protein RBD opening through simulations and experimental validation.

The novel leishmanial Copper P-type ATPase plays a vital role in intracellular parasite survival

This study identifies and characterizes the Leishmania major Cu-ATPase, LmATP7, and demonstrates its role in copper stress resistance and parasite survival within macrophages.

Retromer retrieves the Wilson Disease protein, ATP7B from lysosomes in a copper-dependent mode

The paper shows that retromer facilitates the recycling of the copper transporter ATP7B from lysosomes to the Trans Golgi Network in a copper-dependent manner.