Spatial enrichment of phosphoinositide metabolism is a molecular switch to promote metastasis.
M. Nacke, E. Sandilands, K. Nikolatou, A. Roman-Fernandez, S. Mason, R. Patel, S. Lilla, T. Yelland, L. Galbraith, L. McGarry, J. P. Morton, E. Shanks, H. Y. Leung, S. Zanivan, S. Ismail, , D. Bryant
This study identifies IQSEC1 variants that spatially regulate phosphoinositide metabolism to switch cell behavior from growth to invasion, with implications for metastasis.
bioRxiv · Sep 22, 2020 · PreprintCancer Biology