Author

E. Sandilands

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 5 Organism:human· 5 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Roman-Fernandez· 4 shared D. M. Bryant· 4 shared K. Blyth· 4 shared L. McGarry· 4 shared D. Bryant· 3 shared E. C. Freckmann· 3 shared H. Y. Leung· 3 shared J. C. Norman· 3 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersCancer Biology

A. Roman-Fernandez

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer.

K. Nikolatou, E. Sandilands, A. Roman-Fernandez, E. M. Cumming, E. C. Freckmann, S. Lilla, L. Buetow, L. McGarry, M. Neilson, R. Shaw, D. Strachan, C. Miller, D. T. Huang, I. A. McNeish, J. C. Norman, , D. Bryant

This study identifies ARF6 as a critical vulnerability in PTEN-deficient ovarian cancer, showing its role in integrin-dependent invasion and its inverse association with patient outcomes.

bioRxiv · Nov 29, 2022Cancer Biology

Spatial regulation of the glycocalyx component Podocalyxin is a switch for pro-metastatic function

A. Roman-Fernandez, M. Mansour, F. G. Kugeratski, J. Anand, E. Sandilands, L. Galbraith, K. Rakovic, E. C. Freckmann, E. M. Cumming, J. Park, K. Nikolatou, S. Lilla, R. Shaw, D. Strachan, S. Mason, , D. M. Bryant

This study identifies PODXL as a decoy receptor for GAL3, revealing its role in promoting metastasis through integrin-based invasion and differential cortical targeting regulated by ubiquitination.

bioRxiv · Nov 4, 2022 · PreprintCell Biology

The small GTPase ARF3 controls metastasis and invasion modality by regulating N-cadherin levels.

E. Sandilands, E. C. Freckmann, A. Roman-Fernandez, L. McGarry, L. Galbraith, S. Mason, R. Patel, J. Anand, J. Cartwright, H. Y. Leung, K. Blyth, D. M. Bryant

This study identifies ARF3 as a regulator of invasion modality and metastasis in prostate cancer by controlling N-cadherin levels.

bioRxiv · Apr 25, 2022Cell Biology

RAL GTPases mediate EGFR-driven intestinal stem cell hyperproliferation and tumourigenesis.

M. Naszai, K. Bellec, Y. Yu, A. Roman Fernandez, E. Sandilands, J. Johansson, A. D. Campbell, J. C. Norman, O. J. Sansom, D. Bryant, J. B. Cordero

This study shows RAL GTPases activate EGFR/MAPK signaling in intestinal stem cells, promoting proliferation and tumorigenesis, but are independent of oncogenic RAS.

bioRxiv · Oct 7, 2020 · PreprintCancer Biology

Spatial enrichment of phosphoinositide metabolism is a molecular switch to promote metastasis.

M. Nacke, E. Sandilands, K. Nikolatou, A. Roman-Fernandez, S. Mason, R. Patel, S. Lilla, T. Yelland, L. Galbraith, L. McGarry, J. P. Morton, E. Shanks, H. Y. Leung, S. Zanivan, S. Ismail, , D. Bryant

This study identifies IQSEC1 variants that spatially regulate phosphoinositide metabolism to switch cell behavior from growth to invasion, with implications for metastasis.

bioRxiv · Sep 22, 2020 · PreprintCancer Biology

The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer

R. Millar, A. Kilbey, S.-J. Remak, T. M. Severson, S. Dhayade, E. Sandilands, K. Foster, D. M. Bryant, K. Blyth, S. B. Coffelt

This study identifies the MSP-RON axis as a driver of TNBC growth in a mouse model and shows that inhibiting RON reduces tumor progression.

bioRxiv · Feb 19, 2020Cancer Biology

Fibroblast-derived HGF drives acinar lung cancer cell polarization through integrin-dependent RhoA-ROCK1 inhibition.

A. Datta, E. Sandilands, K. E. Mostov, D. M. Bryant

The paper shows fibroblast-derived HGF induces correct polarity and acinar morphogenesis in lung cancer cells by inhibiting RhoA-ROCK1 via integrin and c-Src signaling.

bioRxiv · Sep 6, 2017Cell Biology