The transcriptional and epigenetic reprogramming associated with chronic IL1β-mediated expansion and myeloid priming in TET2 deficient stem and progenitor cells.
J. McClatchy, R. Strogantsev, E. Wolfe, H.-Y. Lin, M. Mohammadhosseini, B. Davis, C. Eden, D. Goldman, W. Fleming, P. Conley, G. Wu, L. Cimmino, H. Mohammed, A. Agarwal
This study shows IL1β promotes myeloid expansion and self-renewal in TET2-deficient hematopoietic stem/progenitor cells, leading to a premalignant phenotype that can be suppressed by IL1R1 inhibition.
bioRxiv · Sep 15, 2022 · PreprintCancer Biology