Author

W. Fleming

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Pettit· 2 shared B. Jose· 2 shared D. Girard· 2 shared F. Genet· 2 shared H.-W. Tseng· 2 shared J. Gueguen· 2 shared J.-P. Levesque· 2 shared K. Alexander· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPathology

A. Pettit

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The transcriptional and epigenetic reprogramming associated with chronic IL1β-mediated expansion and myeloid priming in TET2 deficient stem and progenitor cells.

J. McClatchy, R. Strogantsev, E. Wolfe, H.-Y. Lin, M. Mohammadhosseini, B. Davis, C. Eden, D. Goldman, W. Fleming, P. Conley, G. Wu, L. Cimmino, H. Mohammed, A. Agarwal

This study shows IL1β promotes myeloid expansion and self-renewal in TET2-deficient hematopoietic stem/progenitor cells, leading to a premalignant phenotype that can be suppressed by IL1R1 inhibition.

bioRxiv · Sep 15, 2022 · PreprintCancer Biology

Spinal cord injury reprograms muscle fibro-adipogenic progenitors to formheterotopic bones within muscles

H.-W. Tseng, D. Girard, K. Alexander, S. Millard, F. Torossian, A. Anginot, W. Fleming, J. Gueguen, M.-E. Goriot, D. Clay, B. Jose, B. Nowlan, A. Pettit, M. Salga, F. Genet, , J.-P. Levesque

This study identifies fibro-adipogenic progenitors (FAPs) as the cells-of-origin for neurogenic heterotopic ossifications (NHO) following spinal cord injury, showing their reprogramming into osteoblasts.

bioRxiv · Nov 4, 2021 · PreprintPathology

Interleukin-1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification

H.-W. Tseng, I. Kulina, D. Girard, J. Gueguen, C. Vaquette, M. Salga, W. Fleming, B. Jose, S. Millard, A. Pettit, K. Schroder, G. Thomas, L. Wheeler, F. Genet, S. Banzet, , J.-P. Levesque

This study shows IL-1 signaling promotes neurogenic heterotopic ossification in mice and humans by activating fibro-adipogenic progenitors.

bioRxiv · Oct 19, 2021Physiology