G. Wu

Systematically investigating and identifying bacteriocins in the human gut microbiome

The paper introduces IIBacFinder to identify unmodified class II bacteriocins in the human gut microbiome, showing their widespread distribution and biosynthetic potential.

The long-chain fatty acid-CoA ligase FadD1 monitors Pseudomonas aeruginosa quorum sensing as a receptor of cis-2-decenoic acid

This paper identifies FadD1 as a receptor for cis-DA quorum sensing in P. aeruginosa, showing it regulates virulence and physiology by binding cis-DA and modulating gene expression.

The Transcription Factor OsNAC5 Mediates Cadmium Stress Response and Accumulation in Rice

This study identifies OsNAC5 as a transcription factor that regulates Cd uptake in rice by activating OsNRAMP1, reducing Cd accumulation in grains.

Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

This study uses scRNA-seq to analyze how chemotherapy remodels the immune landscape and metabolic state in lung adenocarcinoma, identifying changes in macrophage subtypes and immune responses.

ARHGAP32 as a novel RhoGAP interacting with desmoplakin is required for desmosomal organization and assembly

This study identifies ARHGAP32 as a RhoGAP interacting with desmoplakin, essential for desmosomal organization and epithelial cell sheet integrity by regulating actomyosin contractility.

The rapid diversification of Boletales is linked to Early Eocene and Mid-Miocene Climatic Optima

This study links the rapid diversification of Boletales fungi to two climatic optima, showing their expansion coincided with warm-humid climates and host plant diversification.

Analysis of uveal melanoma scRNA sequencing data identifies neoplastic-immune hybrid cells that exhibit metastatic potential

The paper identifies neoplastic-immune hybrid cells in uveal melanoma scRNA-seq data that exhibit metastatic potential through gene expression and ligand-receptor analysis.

Long-Term In Vivo Molecular Monitoring Using Aptamer-Graphene Microtransistors

This paper introduces AGMs for long-term in vivo molecular monitoring, demonstrating detection of dopamine and serotonin in blood and in vivo dopamine release in mice for over a week.

Efficient inhibition of fusion inhibitor HY3000 peptide to SARS-CoV-2 emerging EG.5, EG.5.1 and BA.2.86 variants

This study evaluates the inhibitory activity of the HY3000 peptide against emerging SARS-CoV-2 variants EG.5, EG.5.1, and BA.2.86, finding it retains potent antiviral effects.

Myofibre-specific knockout of TGF-β type I receptors triggers muscle hypertrophy and promotes contraction and oxidative metabolism

This study shows that myofibre-specific knockout of TGF-β type I receptors in mice increases muscle mass, strength, and mitochondrial activity.

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication

This study identifies the role of G3BP1-N interaction in SARS-CoV-2 replication by showing that disrupting this interaction reduces viral replication and pathogenesis.

Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor

This study shows JMJD6 links pre-mRNA splicing and metabolism in MYC-driven cancers, and its inhibition enhances therapeutic response to splicing inhibitors.

Cotyledon Peeling Method for Passion Fruit Protoplasts: a versatile cell system for transient gene expression in passion fruit (Passiflora edulis)

This paper introduces a new method for isolating and transforming passion fruit protoplasts, achieving high yield and transfection efficiency for transient gene expression.

The TRIP6/LATS1 complex constitutes the tension sensor of α-catenin/vinculin at both bicellular and tricellular junctions

This study identifies TRIP6 and LATS1 as novel components of the tension sensor complex at bicellular and tricellular junctions, revealing their distinct distribution and dynamics compared to α-catenin/vinculin.

Guild-level response of the gut microbiota to isocaloric time-restricted feeding in high-fat diet-fed mice

This study shows that time-restricted feeding alters gut microbiota guilds, which are linked to metabolic improvements in high-fat diet-fed mice.

Subtype-specific circadian clock dysregulation modulates breast cancer biology, invasiveness, and prognosis.

This study identifies subtype-specific circadian clock dysregulation in breast cancer, linking it to EMT, invasiveness, and poorer prognosis.

High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen

This study shows that high-altitude hypoxia induces splenic macrophage ferroptosis, reducing erythrophagocytosis and contributing to high-altitude polycythemia.

Free ferrous ions sustain activity of mammalian stearoyl-CoA desaturase-1

This study shows free ferrous ions sustain SCD1 activity by replenishing the diiron center during catalysis, revealing dynamic structural changes and a regulatory role for labile Fe2+ in lipid metabolism.

The Circadian Clock is Disrupted in Pancreatic Cancer

This paper demonstrates circadian clock disruption in human pancreatic cancer using bioinformatics and genetic models, showing dysregulated clock genes and accelerated cancer progression.

A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions

This study analyzes monkeypox virus-host cell interactions using transcriptome data to identify signaling pathways, biomarkers, and potential drug candidates.

Guild-level microbiome signature associated with COVID-19 severity and prognosis

This paper identifies a microbiome guild-level signature associated with COVID-19 severity and prognosis using metagenomic analysis of fecal samples.

The transcriptional and epigenetic reprogramming associated with chronic IL1β-mediated expansion and myeloid priming in TET2 deficient stem and progenitor cells.

This study shows IL1β promotes myeloid expansion and self-renewal in TET2-deficient hematopoietic stem/progenitor cells, leading to a premalignant phenotype that can be suppressed by IL1R1 inhibition.

Productive and latent HIV infections originate in resting CD4+ T cells

This study shows that resting CD4+ T cells are the initial source of both productive and latent HIV infections in the earliest stages of detectable infection.

Phosphorylation and ubiquitination independent endocytosis of BRI1

This study shows that a BR-binding-deficient BRI1 mutant is internalized similarly to wild-type BRI1, suggesting parallel endocytic routes and non-canonical functions.

Detecting sources of immune activation and viral rebound in HIV infection

The paper compares assays for detecting HIV-producing cells and p24 during ART to identify sources of immune activation and viral rebound.

Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice

The paper identifies Muribaculaceae family bacteria as pathobionts that induce insulin-dependent diabetes in mice through translocation to the pancreas following gut microbiota disruption.

Saturated cell lysing is critical for high sensitivity microbiome analysis

This study develops a DNA extraction protocol (LPQ) that achieves saturated cell lysis for microbiome analysis, outperforming existing methods in detecting microbial differences.

Biochemical Characterization of a Fungal Bifunctional Type I Diterpene Synthase Brings a Cryptic Natural Product to Light

The paper identifies a tnd biosynthetic cluster in Aspergillus flavipes and characterizes a bifunctional diterpene synthase, leading to the discovery of talarodiene and its transformation into talaronoid C.

Two Competing Guilds as a Core Microbiome Signature for Health Recovery

The paper identifies two competing bacterial guilds in the gut microbiome that correlate with host health conditions and can classify multiple diseases across diverse populations.

Metformin decreases Cyp26a1 to prevent hepatocarcinogenesis through down- regulating CD8+ T cells

This study shows metformin reduces Cyp26a1 expression, increasing atRA levels and decreasing pro-tumor CD8+ T cells, thereby preventing hepatocarcinogenesis in a mouse model.