H. Mohammed

Mitochondrial-nuclear variation for metabolic plasticity with potential consequences for invasion success in New Zealand mud snails

The paper measures thermal plasticity of metabolic rate in invasive and native asexual lineages of snails, finding invasive lineages have reduced metabolic rates at high temperatures.

Low HER2 enables dedifferentiation and transformation of normal breast epithelial cells via chromatin opening

This study shows that low HER2 levels enable dedifferentiation and transformation of breast epithelial cells through chromatin opening.

The transcriptional and epigenetic reprogramming associated with chronic IL1β-mediated expansion and myeloid priming in TET2 deficient stem and progenitor cells.

This study shows IL1β promotes myeloid expansion and self-renewal in TET2-deficient hematopoietic stem/progenitor cells, leading to a premalignant phenotype that can be suppressed by IL1R1 inhibition.

Allele-specific gene regulation, phenotypes, and therapeutic vulnerabilities in estrogen receptor alpha mutant endometrial cancer

This study investigates ER mutations in endometrial cancer, showing they alter gene expression and promote cancer phenotypes, and identifies potential therapeutic targets.

A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer

This study identifies a unique chromatin state in invasive lobular breast cancer (ILC) driven by FOXA1-ER axis, leading to tamoxifen resistance and poor outcomes.

Aging alters the metabolic flux signature of the ER unfolded protein response in vivo in mice

This study shows that aging in mice leads to an exaggerated and less effective endoplasmic reticulum unfolded protein response (UPRER) under stress, with altered metabolic flux patterns in protein synthesis and lipid production.

Metabolic flux signatures of the ER unfolded protein response in vivo reveal decreased hepatic de novo lipogenesis and mobilization of lipids from adipose tissue to liver

This study uses metabolic labeling and mass spectrometry to analyze UPRER-induced metabolic changes in mouse liver, revealing reduced de novo lipogenesis and lipid mobilization from adipose to liver.

ASXL1 Directs Neutrophilic Differentiation via Modulation of MYC and RNA Polymerase II.

This study identifies ASXL1's role in neutrophil differentiation by modulating MYC and RNA Polymerase II, showing its impact on granulocyte maturation and myeloid malignancies.

Lamina and Heterochromatin Direct Chromosome Organisation in Senescence and Progeria

This study uses polymer physics simulations to show that lamina and heterochromatin interactions drive nuclear organization in senescence and progeria through phase transitions.