Cancer BiologybioRxivPreprint
The transcriptional and epigenetic reprogramming associated with chronic IL1β-mediated expansion and myeloid priming in TET2 deficient stem and progenitor cells.
J. McClatchy, R. Strogantsev, E. Wolfe…·A. Agarwal
This study shows IL1β promotes myeloid expansion and self-renewal in TET2-deficient hematopoietic stem/progenitor cells, leading to a premalignant phenotype that can be suppressed by IL1R1 inhibition.
DOI 10.1101/2022.09.15.507688