Author

D. Levesque

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Assay:behavioral assay· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

F.-M. Boisvert· 5 shared A. Meller· 2 shared M. S. Scott· 2 shared X. Roucou· 2 shared A. Gravel-Chouinard· 1 shared A. Kupai· 1 shared A. N. Bayne· 1 shared A. Servonnet· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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5 shared papersCell Biology

F.-M. Boisvert

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Author profile →

7 papers

Recent·Most cited

The Pseudogene RPS27AP5 Reveals Novel Ubiquitin and Ribosomal Protein Variants Involved in Specialised Ribosomal Functions.

A. Meller, D. Levesque, J. Raisch, E. Fafard-Couture, M. S. Scott, X. Roucou, F.-M. Boisvert

The paper identifies a functional pseudogene, RPS27AP5, that produces ubiquitin and ribosomal protein variants involved in specialized ribosomal functions and transcriptional regulation.

bioRxiv · Feb 5, 2024 · PreprintCell Biology

CRISPR/Cas9-mediated knockout of the ubiquitin variant UbKEKS reveals a role in regulating nucleolar structures and composition.

J. Frion, A. Meller, G. Marbach, D. Levesque, X. Roucou, F.-M. Boisvert

This study shows that UbKEKS regulates nucleolar structure and composition by affecting lamin A accumulation, apoptotic regulator sequestration, and nucleolar morphology.

bioRxiv · Mar 17, 2023 · PreprintCell Biology

Ketolysis is a metabolic driver of CD8+ T cell effector function through histone acetylation

K. M. Luda, S. M. Kitchen-Goosen, E. H. Ma, M. J. Watson, L. R. Duimstra, B. M. Oswald, J. Longo, Z. Fu, Z. Madaj, A. Kupai, B. M. Dickson, I. Kaymak, K. Lau, S. Compton, L. M. DeCamp, , R. G. Jones

This study identifies ketone bodies as essential for CD8+ T cell metabolism and effector function through histone acetylation regulation.

bioRxiv · Aug 26, 2022 · PreprintImmunology

The early endosomal protein Rab21 is critical for enterocyte functions and intestinal homeostasis

S. Nassari, D. Levesque, F.-M. Boisvert, S. Jean

This study shows Rab21 is essential for enterocyte function and intestinal homeostasis in Drosophila, with loss of Rab21 causing morphological defects, increased cell death, and inflammation.

bioRxiv · Nov 18, 2020 · PreprintCell Biology

Dopaminergic mechanisms underlying the expression of antipsychotic-induced dopamine supersensitivity in rats

A. Servonnet, F. Allain, A. Gravel-Chouinard, G. Hernandez, C. Bourdeau Caporuscio, M. Legrix, D. Levesque, P.-P. Rompre, A.-N. Samaha

This study investigates how dopaminergic mechanisms in rats mediate antipsychotic-induced dopamine supersensitivity, finding differential roles for D1 and D2 receptors in modulating behavioral responses to d-amphetamine.

bioRxiv · Sep 8, 2020Pharmacology & Toxicology

Proteomic profiling of mitochondrial-derived vesicles in brain reveals enrichment of respiratory complex sub-assemblies and small TIM chaperones

R. F. Roberts, A. N. Bayne, T. Goiran, D. Levesque, F. M. Boisvert, J.-F. Trempe, E. A. Fon

The paper identifies proteins enriched in brain mitochondrial-derived vesicles (MDVs), revealing OXPHOS proteins and small TIM chaperones, and shows no significant difference in MDV proteomes between wild-type and PINK1-/- or Parkin-/- mice.

bioRxiv · Jul 6, 2020Biochemistry

Human Hepatocyte Nuclear Factor 4-α encodes isoforms with distinct transcriptional functions

E. Lambert, J.-P. Babeu, J. Simoneau, D. Levesque, E. Jolibois, M. S. Scott, F. Boudreau, F.-M. Boisvert

The paper characterizes the transcriptional functions of 12 HNF4 isoforms, finding significant differences in their regulatory activity and identifying specific partners and mechanisms.

bioRxiv · Mar 21, 2019Cell Biology