F. Cominelli

TL1A/DR3 signaling regulates the generation of pathogenic Th9 cells in experimental inflammatory bowel disease

This study shows that DR3 signaling promotes Th9 cell pathogenicity in CD-like ileitis by enhancing pro-inflammatory signatures and reducing anti-inflammatory responses.

Mesenchymal stem cells ameliorate inflammation in an experimental model of Crohn's disease via the mesentery

This study shows that mesenchymal stem cells (MSCs) reduce inflammation in a mouse model of Crohn's disease by modulating T cells and macrophages in the mesentery, with long-term effects through macrophage reprogramming.

Diet prevents the expansion of segmented filamentous bacteria and ileo-colonic inflammation in a model of Crohn's disease

This study shows that diet can prevent ileo-colonic inflammation in a Crohn's disease model by reducing segmented filamentous bacteria (SFB) abundance.

Nonmedical Masks in Public for Respiratory Pandemics: Droplet Retention by two-layer Textile Barrier Fully Protects Germ-free Mice from Bacteria in Droplets

This study shows that two-layer household textiles effectively prevent bacterial droplet contamination in germ-free mice, demonstrating their potential as a universal droplet barrier.

Patterns of 'Analytical Irreproducibility' in Multimodal Diseases

This paper shows that increasing sample size in multimodal disease studies does not guarantee reproducibility due to data subtypes and variability, and proposes using kernel-density-violin plots to better understand disease subtypes.

Understanding artificial mouse-microbiome heterogeneity and six actionable themes to increase study power

The paper identifies six actionable themes to reduce artificial heterogeneity in mouse-microbiome studies by addressing statistical and practical issues in housing density and data analysis.