Mesenchymal stem cells ameliorate inflammation in an experimental model of Crohn's disease via the mesentery
M. Dave, A. Dev, R. A. Somoza, N. Zhao, S. Viswanath, P. R. Mina, P. Chirra, V. C. Obmann, G. H. Mahabeleshwar, P. Menghini, B. D. Johnson, J. A. Nolta, C. Soto, A. Osme, L. T. Khuat, , F. Cominelli
This study shows that mesenchymal stem cells (MSCs) reduce inflammation in a mouse model of Crohn's disease by modulating T cells and macrophages in the mesentery, with long-term effects through macrophage reprogramming.
bioRxiv · May 22, 2023 · PreprintImmunology