Structural basis for targeting the human T-cell leukemia virus Tax oncoprotein and syntenin-1 interaction using a small molecule
S. Maseko, I. Van Molle, K. Blibek, C. Gorgulla, J. Olivet, J. Blavier, C. Vandermeulen, S. Skupiewski, D. Saha, T. Ntombela, J. Lim, F. Lembo, A. Beauvois, M. Hamaidia, J.-P. Borg, , J.-C. Twizere
This study identifies the structural basis of Tax-1 interaction with syntenin-1 and demonstrates small-molecule inhibition of this interaction to target HTLV-1.
bioRxiv · Aug 25, 2021 · PreprintBiochemistry