S. Pfister

Land-use impacts on plant functional diversity throughout Europe

The paper assesses how human land use affects plant functional diversity across Europe, finding lower functional richness and divergence but higher evenness in disturbed areas.

Somatic gene delivery for flexible in vivo modeling of high-risk sarcoma

This paper develops a mouse model for high-risk sarcoma by delivering genetic lesions via electroporation, generating multiple sarcoma types and validating their molecular and therapeutic relevance.

Zika virus remodels and hijacks IGF2BP2 ribonucleoprotein complex to promote viral replication organelle biogenesis

This study identifies IGF2BP2 as a host factor hijacked by ZIKV to regulate viral replication organelle biogenesis and vRNA synthesis.

Spatial and temporal transcriptomics of SHH-medulloblastoma with chromothripsis identifies multiple genetic clones that resist to treatment and lead to relapse

This study uses spatial transcriptomics to analyze chromothriptic medulloblastomas, revealing higher intra-tumour heterogeneity, treatment resistance, and relapse mechanisms through clone-specific features.

Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level

This study identifies subtype-specific proteome and N-glycan alterations in medulloblastoma that may serve as therapeutic targets.

Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways

The paper identifies shared molecular features between H3K27M diffuse midline gliomas and PFA ependymomas, linking them to hindbrain developmental pathways.

Plant secondary metabolite-dependent plant-soil feedbacks can improve crop yield in the field

This study shows that maize secondary metabolites improve wheat yield and growth through soil feedbacks in field conditions.

A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis

The paper identifies a synergistic effect between HDAC and PARP inhibitors in childhood tumors with chromothripsis, validated through drug screening and in vivo models.

Biomolecular solid-state NMR spectroscopy at highest field: the gain in resolution at 1200 MHz

This paper demonstrates improved resolution in biomolecular solid-state NMR spectroscopy at 1200 MHz, showing higher peak resolution in 13C spectra and aliphatic side-chain resonances in 1H spectra compared to 850 MHz.

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

The paper identifies chromothripsis and chromoanasynthesis in tumors with DNA repair deficiencies and links them to MYC/MYCN amplification and therapeutic opportunities.