Insulin receptor substrate 4 deficiency mediates the insulin effect on the epithelial magnesium channel TRPM6 and causes hypomagnesemia
J. Zhang, S. W. An, S. Neelam, A. Bhatta, M. Nie, C. Duran, M. Bal, F. Latta, J. S. Hou, J. J. Otto, J. Kozlitina, A. Lemoff, J. Hoenderop, M. Baum, M. T. Wolf
This paper identifies IRS4 as a novel regulator of TRPM6 channel activity and Mg2+ homeostasis, showing IRS4 mediates insulin's effect on TRPM6 phosphorylation and Mg2+ absorption.
bioRxiv · Oct 1, 2022 · PreprintPhysiology