PhysiologybioRxivPreprint
Insulin receptor substrate 4 deficiency mediates the insulin effect on the epithelial magnesium channel TRPM6 and causes hypomagnesemia
J. Zhang, S. W. An, S. Neelam…·M. T. Wolf
This paper identifies IRS4 as a novel regulator of TRPM6 channel activity and Mg2+ homeostasis, showing IRS4 mediates insulin's effect on TRPM6 phosphorylation and Mg2+ absorption.
DOI 10.1101/2022.10.01.510479