M. James

Multi-scale phenotyping of senescence-related changes in roots of rapeseed in response to nitrogen deficiency

The paper characterizes senescence-related changes in rapeseed roots under nitrogen deficiency, identifying markers and proteomic changes associated with nutrient remobilization.

DERIVATION OF ELEPHANT INDUCED PLURIPOTENT STEM CELLS

This paper reports the first derivation of elephant induced pluripotent stem cells (emiPSCs) using a modified reprogramming protocol that inhibits TP53 expansion genes.

Quantifying forms and functions of intestinal bile acid pools in mice

The paper quantifies ileal bile acid pools in mice and shows that Asbt-mediated transport dominates their size and composition, with loss of Asbt reducing pool size and altering transcriptional responses.

Lysinoalanine crosslinking is a conserved post-translational modification in the spirochete flagellar hook

The paper identifies lysinoalanine (Lal) crosslinks in spirochete flagellar hooks across multiple species, showing they are conserved and necessary for motility.

Autophagic activity acts as a rheostat in the control of nitrogen transfer from Arabidopsis rosette leaves to the seeds according to a principle of communicating vessels

This study shows autophagy regulates nitrogen transfer from Arabidopsis leaves to seeds, with over-expressors performing better under nitrate sufficiency and mutants showing defects in nitrogen remobilization and seed production.

Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole genome sequencing with histopathological features

This study integrates multi-region whole genome sequencing with histopathological data to reconstruct tumour phylogenies and identify molecular steps in prostate cancer progression and metastasis.

Transcriptomic and functional analysis of ANGPTL4 overexpression in pancreatic cancer nominates targets that reverse chemoresistance

This study identifies ANGPTL4-driven genes that reverse chemoresistance in pancreatic cancer by targeting ITGB4 and APOL1.

Persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for the fast acting opioid remifentanil

This study examines the persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for remifentanil, showing prolonged behavioral changes beyond drug availability.

Adaptor protein Bbc1 regulates localization of Wsp1 and Vrp1 during endocytic actin patch assembly

This study identifies Bbc1 as a regulator of Wsp1 and Vrp1 localization during endocytic actin patch assembly in S. pombe by disrupting Myo1 interactions.