F. Oliveira

Increasing the vitamin C transporter SVCT2 in microglia improves synaptic plasticity and restrains memory impairments in Alzheimer's disease models

This study shows that increasing SVCT2 in microglia reduces amyloid plaques, improves synaptic plasticity, and enhances memory in Alzheimer's disease models.

Improved prediction of site-rates from structure with averaging across homologs

The paper shows that averaging site-specific mutation rates across homologous protein structures improves predictions of site-rates from structure.

Genetic exchange in Leishmania is facilitated by IgM natural antibodies

This study shows IgM antibodies facilitate Leishmania genetic hybridization in vitro and in vivo, leading to full genome hybrids and increased genetic exchange.

First-in-human evaluation of cutaneous innate and adaptive immunomodulation by mosquito bites

This study evaluates immune responses to mosquito bites in humans, identifying key genes, cell types, and pathways involved in innate and adaptive immunity.

A Second Generation Leishmanization Vaccine with a Markerless Attenuated Leishmania major Strain using CRISPR gene editing

This paper describes a CRISPR-edited Leishmania major strain for a second-generation leishmanization vaccine that is marker-free and safe, showing protection in mice comparable to traditional leishmanization.

Leishmania infection induces a limited differential gene expression in the sand fly midgut

This study uses RNA-Seq to analyze midgut gene expression changes in sand flies infected with Leishmania, finding limited differential expression with stage-specific effects.

Distinct gene expression patterns in vector-residing Leishmania infantum identify parasite stage-enriched markers

The paper identifies stage-specific gene expression markers in Leishmania infantum during its development in the sand fly vector using RNAseq and differential expression analysis.