Author

P. Lypaczewski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

G. Matlashewski· 4 shared C. Meneses· 2 shared G. Volpedo· 2 shared J. G. Valenzuela· 2 shared J. Oristian· 2 shared N. Ismail· 2 shared R. DEY· 2 shared S. Gannavaram· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

G. Matlashewski

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Diversity of Vibrio cholerae O1 through the human gastrointestinal tract during cholera

P. Lypaczewski, D. Chac, C. N. Dunmire, K. M. Tandoc, F. Chowdhury, A. I. Khan, T. Bhuiyan, J. B. Harris, R. C. LaRocque, S. B. Calderwood, E. T. Ryan, F. Qadri, B. J. Shapiro, A. A. Weil

This study compares genetic diversity of Vibrio cholerae O1 in vomit and stool from cholera patients, finding reduced diversity in stool and some gene loss between samples.

bioRxiv · Feb 8, 2024Microbiology

Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis

S. Karmakar, G. Volpedo, W.-W. Zhang, P. Lypaczewski, N. Ismail, L. F. Oliveira, J. Oristian, C. Meneses, S. Gannavaram, S. Kamhawi, S. Hamano, J. G. Valenzuela, R. DEY, A. R. Satoskar, G. Matlashewski, H. Nakhasi

This study shows that centrin-deficient L. mexicana parasites protect against Old World visceral leishmaniasis in a hamster model by reducing parasite burden and altering cytokine responses.

bioRxiv · Jun 27, 2022Immunology

Evidence that interspecies Leishmania hybrids contribute to changes in disease pathology

P. Lypaczewski, G. Matlashewski

This study identifies interspecies Leishmania hybrids in Sri Lanka that may explain atypical cutaneous leishmaniasis, suggesting hybridization contributes to disease pathology changes.

The Lancet Microbe · Jun 1, 2021Peer-reviewedMicrobiology

Characterization of a new Leishmania major isolate for use in a controlled human infection model

H. Ashwin, J. Sadlova, B. Vojtkova, T. Becvar, P. Lypaczewski, E. Schwartz, E. Greensted, K. Van Bocxlaer, M. Pasin, K. Lipinski, V. Parkash, G. Matlashewski, A. Layton, C. Lacey, C. Jaffe, , P. Kaye

This paper isolates and characterizes a new Leishmania major strain for use in controlled human infection models to advance vaccine development.

bioRxiv · Aug 12, 2020Microbiology

A Second Generation Leishmanization Vaccine with a Markerless Attenuated Leishmania major Strain using CRISPR gene editing

W. W. Zhang, S. Karmakar, S. Gannavaram, R. Dey, P. Lypaczewski, N. Ismail, A. Siddiqui, V. Simonyan, F. Oliveira, I. V. Coutinho-Abreu, T. DeSouza-Vieira, C. Meneses, J. Oristian, T. D. Serfim, A. Musa, , H. L. Nakhasi

This paper describes a CRISPR-edited Leishmania major strain for a second-generation leishmanization vaccine that is marker-free and safe, showing protection in mice comparable to traditional leishmanization.

bioRxiv · May 4, 2020Microbiology