R. Dey

Extracellular caspase-1 regulates hair follicle stem cell migration during wound-healing

This study identifies extracellular Caspase-1 as a chemoattractant that drives hair follicle stem cell migration during wound healing.

Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis

This study shows that centrin-deficient L. mexicana parasites protect against Old World visceral leishmaniasis in a hamster model by reducing parasite burden and altering cytokine responses.

Mindin is essential for cutaneous fibrogenesis in a new mouse model of systemic sclerosis

This study identifies Mindin as a key driver of fibrosis in a new mouse model of systemic sclerosis, showing its role in inducing inflammation and collagen production in fibroblasts.

Skin resident memory cells generated by the L. major centrin gene deleted parasites mediate protective immune response analogous to leishmanization

This study shows that a genetically modified Leishmania vaccine generates skin-resident memory T cells that provide protection similar to leishmanization.

The initiation of the wound healing program is regulated by the convergence of mechanical and epigenetic cues

This study identifies how mechanical tension in the epidermis triggers DNA methylation changes via DNMT3a, leading to gene expression shifts that initiate wound healing.

Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of the matricellular protein Mindin

This study identifies Snail's role in maintaining stem/progenitor state in skin epithelial cells and carcinomas via Mindin-mediated autocrine signaling.

Active microrheology using pulsed optical tweezers to probe viscoelasticity of Lamin A towards diagnosis of laminopathies

This study uses active microrheology with optical tweezers to measure viscoelastic changes in lamin A mutants, linking structural alterations to disease mechanisms in laminopathies.

Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasis

This study evaluates the protective efficacy of a CRISPR-edited Leishmania major strain against visceral leishmaniasis in hamsters and shows it induces a pro-inflammatory immune response and prevents disease.

A Second Generation Leishmanization Vaccine with a Markerless Attenuated Leishmania major Strain using CRISPR gene editing

This paper describes a CRISPR-edited Leishmania major strain for a second-generation leishmanization vaccine that is marker-free and safe, showing protection in mice comparable to traditional leishmanization.