RAS activation via CRLF2 signaling is a widespread mechanism in Down syndrome acute lymphoblastic leukemia regardless of RAS mutations
D. Koschut, D. Ray, Z. Li, E. Giarin, J. Groet, I. Alic, S. K.-Y. Kham, W.-J. Chng, H. Ariffin, D. M. Weinstock, A. E.-J. Yeoh, G. Basso, D. Nizetic
This study shows that RAS activation via CRLF2 signaling is common in DS-ALL regardless of RAS mutations and is predictive of poor outcomes.
bioRxiv · Feb 3, 2020Cancer Biology