D. Ray

The dynamic crosstalk between cytoskeletal filaments regulates the cytoplasmic mechanics across the apicobasal axis

The paper investigates how cytoskeletal filaments influence cytoplasmic viscoelasticity along the apicobasal axis, showing that actin and vimentin dynamics regulate mechanical properties in different regions.

Conditional Generative Learning for Medical Image Imputation

This paper develops a generative algorithm for medical image imputation, showing it outperforms deterministic deep learning methods and provides confidence measures for imputed images.

Viability of carcass removal as an option for offsetting the incidental take of golden eagles (Aquila chrysaetos) at wind energy facilities

The paper evaluates carcass removal as a mitigation strategy to offset golden eagle mortalities at wind energy facilities, finding it viable with potential to save up to seven eagles per year in some counties.

A Suite of Advanced Tutorials for the WESTPA 2.0 Rare-Events Sampling Software

The paper provides advanced tutorials for WESTPA 2.0, demonstrating new features for rare-events sampling in molecular simulations.

Force Field Dependent DNA Breathing Dynamics: A Case Study of Hoogsteen Base Pairing in A6-DNA

This paper investigates how different force field models affect the WC to HG base pair transition in DNA, finding that enthalpic stabilization and entropy balance determine conformational stability.

Probing the role of macromolecular crowding in cell volume regulation using fluorescence anisotropy

This study investigates the role of macromolecular crowding in cell volume regulation using fluorescence anisotropy and finds that cytoplasmic MMC is not a sensor for volume regulation, while membrane tension is critical.

Probabilistic Brain Extraction in MR Images via Conditional Generative Adversarial Networks

This paper introduces a probabilistic deep learning method for brain extraction in MR images using cGANs, showing improved accuracy and uncertainty quantification compared to existing tools.

Pectin self-assembly and its disruption by water: Insights into plant cell wall mechanics

This study investigates how dehydration and rehydration affect pectin-Ca gel mechanics and microstructure, revealing irreversible changes with increasing dehydration.

The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians

This study identifies Mbnl3 as a placenta-specific X-linked gene that restricts placental growth in eutherians through altered RNA binding specificities and novel biological functions.

Point Mutations in SARS-CoV-2 Variants Induce Long-Range Dynamical Perturbations in Neutralizing Antibodies

This study shows how point mutations in SARS-CoV-2 variants alter the dynamics of neutralizing antibodies, affecting their binding affinity and structure.

Markovian Weighted Ensemble Milestoning (M-WEM): Long-time Kinetics from Short Trajectories

This paper introduces M-WEM, a method to calculate long-timescale biomolecular kinetics from short simulations, showing high accuracy and low computational cost.

Distant Residues Modulate Conformational Opening in SARS-CoV-2 Spike Protein

This paper identifies non-RBD residues in SARS-CoV-2 spike protein that modulate conformational changes critical for receptor binding, offering targets for broad-spectrum therapeutics.

Mutant EGFR is a preferred SMURF2 substrate of ubiquitination: role in enhanced receptor stability and TKI sensitivity

This paper identifies SMURF2-mediated ubiquitination of EGFR mutants as a mechanism enhancing receptor stability and TKI sensitivity.

RAS activation via CRLF2 signaling is a widespread mechanism in Down syndrome acute lymphoblastic leukemia regardless of RAS mutations

This study shows that RAS activation via CRLF2 signaling is common in DS-ALL regardless of RAS mutations and is predictive of poor outcomes.

Free Energy Landscape and Conformational Kinetics of Hoogsteen Base-Pairing in DNA vs RNA

This study uses simulations to analyze the free energy and kinetics of Hoogsteen base pairing in DNA and RNA, revealing distinct transition pathways and intermediates.

Electrospray sample injection for single-particle imaging with X-ray lasers

This paper demonstrates an electrospray injector that reduces aerosol droplet size, enabling contaminant-free sample delivery for single-particle imaging with X-ray lasers.