D. M. Weinstock

Leukemia circulation kinetics revealed through blood exchange method

This study uses a blood exchange method in mouse leukemia models to show that leukemia cells circulate longer than solid tumor cells and that microenvironmental factors like E-selectin influence their clearance.

Targeting TRIP13 in Wilms Tumor with Nuclear Export Inhibitors

This study identifies XPO1 inhibition with selinexor as a potential therapy for favorable histology Wilms tumors, showing synergy with doxorubicin in preclinical models.

Micro-region transcriptomics of fixed human tissue using Pick-Seq

Pick-Seq enables deep spatial transcriptomic profiling of fixed human tissue, revealing transcriptional differences in tumor invasion, proliferation, and immuno-editing.

Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis

The paper identifies sex-biased ZRSR2 mutations in BPDCN that impair pDC activation and apoptosis, linking X chromosome mutations to male-predominant leukemia.

Signaling input from divergent pathways subverts malignant B-cell transformation

This study shows that malignant B-cell transformation requires convergence on a single oncogenic pathway, while divergent pathways can subvert transformation and are targets for new therapeutic strategies.

RAS activation via CRLF2 signaling is a widespread mechanism in Down syndrome acute lymphoblastic leukemia regardless of RAS mutations

This study shows that RAS activation via CRLF2 signaling is common in DS-ALL regardless of RAS mutations and is predictive of poor outcomes.

Parp3 promotes long-range end-joining in murine cells

This study shows Parp3 promotes chromosomal rearrangements in murine cells, contrasting with Parp1's suppressive role in DNA double-strand break processing.