Sprouty4 is required for Mdm2 regulation of invasion, focal adhesion formation and metastasis in cells lacking p53.
R. M. de Queiroz, G. Efe, A. Guzman, N. Hashimoto, Y. Kawashima, T. Tanaka, A. K. Rutsgi, C. Prives
The paper shows that Mdm2 and MdmX regulate cell migration, invasion, and metastasis through Sprouty4 in p53-deficient cells.
bioRxiv · May 8, 2023Cancer Biology