Author

K.-P. Ko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Organism:human· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2

Frequent Co-Authors

G. Zou· 6 shared J. Zhang· 6 shared J.-I. Park· 6 shared S. Jun· 6 shared S. Zhang· 6 shared Y. Huang· 6 shared B. Kim· 5 shared K.-S. PARK· 3 shared

Activity by Year

2022-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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6 shared papersCancer Biology

G. Zou

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

CRACD suppresses neuroendocrinal plasticity of lung adenocarcinoma

B. Kim, S. Zhang, Y. Huang, K.-P. Ko, G. Zou, J. Zhang, S. Jun, K.-B. Kim, Y.-S. Jung, K.-S. PARK, J.-I. Park

This study shows CRACD suppresses neuroendocrinal plasticity in lung adenocarcinoma by restricting cell de-differentiation and stemness-related pathways.

bioRxiv · Apr 19, 2023 · PreprintCancer Biology

CDH1 loss defines distinct diffuse-gastric cancer subtype with T cell exhaustion and EZH2 regulon activation

G. Zou, Y. Huang, S. Zhang, K.-P. Ko, B. J. Kim, J. Zhang, V. Venkatesan, M. P. Pizzi, S. Jun, N. Niu, H. Wang, S. Song, J. A. Ajani, J.-I. Park

This study identifies two distinct subtypes of diffuse-type gastric cancer associated with CDH1 loss, highlighting T cell exhaustion and EZH2 regulon activation.

bioRxiv · Mar 23, 2023Cancer Biology

Tumor Niche Network-Defined Subtypes Predict Immunotherapy Response of Esophageal Squamous Cell Cancer

K.-P. Ko, S. Zhang, Y. Huang, B. Kim, G. Zou, S. Jun, J. Zhang, C. Martin, K. J. Dunbar, G. Efe, A. K. Rustgi, H. Zhang, H. Nakagawa, J.-I. Park

This study defines ESCC subtypes based on tumor microenvironment transcriptional networks and predicts immunotherapy response using single-cell transcriptomics.

bioRxiv · Feb 15, 2023Cancer Biology

Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer

Y. Seo, S. Zhang, J. Jang, K.-P. Ko, K.-B. Kim, Y. Huang, D.-W. Kim, B. Kim, G. Zou, J. Zhang, S. Jun, W. Chu, N. A. Kirk, Y. E. Hwang, Y. H. Ban, , J.-I. Park

This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.

bioRxiv · Feb 15, 2023Cancer Biology

Key Genetic Determinants Driving Esophageal Squamous Cell Carcinoma Initiation and Immune Evasion

K.-P. Ko, Y. Huang, S. Zhang, G. Zou, B. Kim, J. Zhang, S. Jun, C. Martin, K. J. Dunbar, G. Efe, A. K. Rustgi, H. Nakagawa, J.-I. Park

This study identifies key genetic drivers of ESCC initiation and immune evasion using CRISPR/Cas9 in murine organoids and human scRNA-seq data.

bioRxiv · Oct 13, 2022Cancer Biology

PCLAF-DREAM Drives Alveolar Cell Plasticity for Lung Regeneration

B. Kim, Y. Huang, K.-P. Ko, S. Zhang, G. Zou, J. Zhang, M. Kim, D. Little, L. V. Ellis, M. Paschini, S. Jun, K.-S. Park, J. Chen, C. Kim, J.-I. Park

This study identifies PCLAF-DREAM's role in alveolar cell plasticity during lung regeneration and shows a drug candidate can pharmacologically target this process to prevent fibrosis.

bioRxiv · Oct 11, 2022Cell Biology