Author

A. K. Rustgi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3

Frequent Co-Authors

H. Nakagawa· 3 shared B. Kim· 2 shared C. Martin· 2 shared G. Efe· 2 shared G. Zou· 2 shared J. Zhang· 2 shared J.-I. Park· 2 shared K. J. Dunbar· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

H. Nakagawa

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

Y. Zhang, D. Karagiannis, H. Liu, M. Lin, Y. Fang, M. Jiang, X. Chen, S. Suresh, H. Huang, J. She, F. Shi, P. Yang, W. El-Rifai, A. Zaika, A. E. Oro, , J. Que

This study shows that p63 regulates the balance between squamous and neuroendocrine cell fates in esophageal development and cancer by modulating epigenetic mechanisms.

Science Advances · Oct 11, 2024Peer-reviewedCell Biology

The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation

E. Fernandez Garcia, U. Paudel, M. C. Noji, C. E. Bowman, J. R. Pitarresi, A. K. Rustgi, K. E. Wellen, Z. Arany, J. S. Weissenrieder, J. K. Foskett

This study shows that the mitochondrial Ca2+ channel MCU supports tumor growth by enabling cell cycle progression and proliferation through mitochondrial Ca2+ uptake, despite unchanged mitochondrial function.

bioRxiv · Apr 26, 2023 · PreprintCancer Biology

Tumor Niche Network-Defined Subtypes Predict Immunotherapy Response of Esophageal Squamous Cell Cancer

K.-P. Ko, S. Zhang, Y. Huang, B. Kim, G. Zou, S. Jun, J. Zhang, C. Martin, K. J. Dunbar, G. Efe, A. K. Rustgi, H. Zhang, H. Nakagawa, J.-I. Park

This study defines ESCC subtypes based on tumor microenvironment transcriptional networks and predicts immunotherapy response using single-cell transcriptomics.

bioRxiv · Feb 15, 2023Cancer Biology

Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma 3D organoids and identify matrix-activated therapeutic targets

R. Cruz-Acuna, S. W. Kariuki, K. Sugiura, C. Loebel, T. Karakasheva, J. T. Gabre, J. A. Burdick, A. K. Rustgi

The paper develops a hydrogel platform to study matrix mechanics in EAC organoids and identifies therapeutic targets for ECM stiffness.

bioRxiv · Nov 13, 2022 · PreprintBioengineering

Key Genetic Determinants Driving Esophageal Squamous Cell Carcinoma Initiation and Immune Evasion

K.-P. Ko, Y. Huang, S. Zhang, G. Zou, B. Kim, J. Zhang, S. Jun, C. Martin, K. J. Dunbar, G. Efe, A. K. Rustgi, H. Nakagawa, J.-I. Park

This study identifies key genetic drivers of ESCC initiation and immune evasion using CRISPR/Cas9 in murine organoids and human scRNA-seq data.

bioRxiv · Oct 13, 2022Cancer Biology

Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment

N. Li, Q. Zhu, Y. Tian, K. J. Ahn, X. Wang, Z. Cramer, I. W. Folkert, P. Yu, J. Jou, S. Adams-Tzivelekidis, P. Sehgal, N. N. Mahmoud, C. B. Aarons, R. E. Roses, A. Thomas-Tikhonenko, , C. J. Lengner

This study maps and models human colorectal carcinoma interactions with the tumor microenvironment using single-cell transcriptomics and tumoroid cultures, showing how tumoroids suppress inflammation and reprogram macrophages.

bioRxiv · Sep 13, 2022Cancer Biology

Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models

N. D. Facompre, P. Rajagopalan, V. Sahu, A. T. Pearson, K. T. Montone, C. D. James, F. O. Gleber-Netto, G. S. Weinstein, J. Jalaly, A. Lin, A. K. Rustgi, H. Nakagawa, J. A. Califano, C. R. Pickering, E. A. White, , D. Basu

This study identifies predictors of HPV-related head and neck squamous cell carcinoma progression and survival using patient-derived models and finds associations between mutational burden and E2F target dysregulation with clinical outcomes.

bioRxiv · Jun 17, 2019Cancer Biology