Author

G. Ercoli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. S. Brown· 2 shared A. Kadiloglu· 1 shared A. Proust· 1 shared B. W. Wren· 1 shared C. P. Kyriacou· 1 shared D. Carreno· 1 shared D. G. Lalloo· 1 shared D. S. Ferreira· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersMicrobiology

J. S. Brown

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The Streptococcus pneumoniae transcriptome in patient cerebrospinal fluid identifies novel virulence factors required for meningitis

E. C. Wall, J.-A. Guerra-Assuncao, M. Yang, R. Konig, T. Audshasai, A. Proust, R. Aprianto, E. Ramos-Sevillano, G. Ercoli, N. Bordin, V. S. Agostinho-Terra, J.-W. Veening, D. G. Lalloo, B. W. Wren, R. J. Wilkinson, , J. S. Brown

The paper uses RNA sequencing of cerebrospinal fluid from meningitis patients to identify S. pneumoniae virulence factors, finding two genes linked to increased mortality and reduced infection persistence.

bioRxiv · Apr 30, 2024 · PreprintMicrobiology

Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae

E. Ramos Sevillano, G. Ercoli, M. Betts, J. A. Guerra-Assuncao, F. Partridge, V. Silva Entrudo Fernandes, E. Wall, S. Gordon, D. S. Ferreira, R. Heyderman, J. S. Brown

This study shows that one-carbon metabolism is essential for Streptococcus pneumoniae virulence, while proline biosynthesis has a strain-dependent role in systemic infection.

bioRxiv · Aug 3, 2023 · PreprintMicrobiology

Diurnal differences in intracellular replication within splenic macrophages correlates with the outcome of pneumococcal infection.

R. G. Hames, Z. Jasiunaite, G. Ercoli, J. J. Wanford, D. Carreno, K. Straatman, L. Martinez-Pomares, H. Yesilkaya, S. Glenn, E. R. Moxon, P. W. Andrew, C. P. Kyriacou, M. R. Oggioni

This study shows that pneumococcal infection in mice during their active phase leads to faster septicaemia onset and higher bacterial burden in splenic macrophages compared to rest phase infection.

bioRxiv · Jan 30, 2022Microbiology