Author

G. Laengst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:ATAC-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

H. Wodrich· 2 shared U. Schwartz· 2 shared A. Celle· 1 shared A. Hoischen· 1 shared A. Papantonis· 1 shared A. Rada-Iglesias· 1 shared A. Zirkel· 1 shared B. Wollnik· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

H. Wodrich

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The long non-coding RNA MALAT1 modulates NR4A1 expression through a downstream regulatory element in specific cancer-cell-types

S. Wernig-Zorc, U. Schwartz, G. Laengst, R. Maldonado

This study identifies MALAT1's role in regulating NR4A1 expression via a downstream regulatory element in specific cancer cell types using RNA- and ATAC-seq.

bioRxiv · Mar 9, 2023Cell Biology

SARS-CoV-2 transmission via apical syncytia release from primary bronchial epithelia and infectivity restriction in children epithelia

G. Beucher, M.-L. Blondot, A. Celle, N. Pied, P. Recordon-Pinson, P. Esteves, M. Faure, M. Metifiot, S. Lacomme, D. Dacheaux, D. R. Robinson, G. Laengst, F. Beaufils, M.-E. Lafon, P. Berger, , H. Wodrich

This study shows that adult bronchial epithelia form infectious syncytia releasing SARS-CoV-2, while children's epithelia resist infection due to faster interferon response.

bioRxiv · May 28, 2021Microbiology

Adenoviral chromatin organization primes for early gene activation

U. Schwartz, T. Komatsu, C. Huber, F. Lagadec, C. Baumgartl, E. Silberhorn, M. Nuetzel, F. Rayne, E. Basyuk, E. Bertrand, M. Rehli, H. Wodrich, G. Laengst

This study investigates adenovirus chromatin organization during early infection, revealing structural dynamics and their correlation with gene activation.

bioRxiv · Jul 7, 2020 · PreprintCell Biology

Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology

Y. Kargapolova, R. Rehimi, H. Kayserli, J. Bruehl, A. Zirkel, Y. Li, G. Yigit, A. Hoischen, S. Frank, N. Russ, J. Trautwein, M. Laugsch, E. G. Gusmao, N. Josipovic, J. Altmeuller, , A. Papantonis

The paper identifies a CHD6 mutation causing Hallermann-Streiff syndrome and shows it disrupts autophagy and DNA damage response through chromatin remodeling.

bioRxiv · Jan 27, 2020Cell Biology