Author

H. Biebermann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

G. Kleinau· 2 shared P. Scheerer· 2 shared A. Beck-Sickinger· 1 shared A. Brenlla-Lopez· 1 shared A. G. Beck-Sickinger· 1 shared A. Koch· 1 shared A. Morton· 1 shared A. Schmidt· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPharmacology & Toxicology

G. Kleinau

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2 papers

Recent·Most cited

MRAP2 modifies signaling and oligomerization state of the melanocortin-4 receptor

I. Sohail, S.-A. Laurin, G. Kleinau, V. Chunilal, A. Morton, A. Brenlla-Lopez, Z. C. U. Kagiali, J. A. Tello, M.-J. Blouin, A. G. Beck-Sickinger, M. J. Lohse, P. Scheerer, M. Bouvier, P. McCormick, P. Annibale, H. Biebermann

This study shows that MRAP2 modifies MC4R signaling and oligomerization, enhancing G protein signaling while reducing beta-arrestin2 recruitment and receptor internalization.

bioRxiv · Apr 9, 2024Pharmacology & Toxicology

Structures of active melanocortin-4 receptor--Gs-protein complexes with NDP-α-MSH and setmelanotide

N. A. Heyder, G. Kleinau, D. Speck, A. Schmidt, S. Paisdzior, M. Szczepek, B. Bauer, A. Koch, M. Gallandi, D. Kwiatkowski, J. Bürger, T. Mielke, A. Beck-Sickinger, P. W. Hildebrand, C. M. T. Spahn, , P. Scheerer

The paper presents cryo-EM structures of MC4R-Gs complexes with NDP-α-MSH and setmelanotide, revealing ligand-specific interactions and activation mechanisms.

bioRxiv · Apr 22, 2021Biochemistry