CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation epigenetically and inflammatory signaling through a short, encoded peptide
H. Halasz, E. Malekos, S. Covarrubias, S. Yitiz, C. Montano, L. Sudek, S. Katzman, S. J. Liu, M. A. Horlbeck, J. S. Weissman, S. Carpenter
The paper uses CRISPRi screens to identify the lncRNA LOUP as a regulator of macrophage differentiation and inflammatory signaling through epigenetic and peptide-mediated mechanisms.
bioRxiv · Dec 19, 2023 · PreprintImmunology