Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
L. Duplaquet, K. So, A. W. Ying, X. Li, Y. Li, X. Qiu, R. Li, S. Singh, X. S. Wu, Q. Liu, J. Qi, T. D. D. Somerville, H. Heiling, E. Mazzola, Y. Lee, , M. G. Oser
This study identifies mSWI/SNF complex activity as a targetable dependency in POU2F3-positive small cell lung cancer, showing that inhibiting mSWI/SNF or BRD9 reduces tumor growth and improves survival.
bioRxiv · Jan 21, 2024Cancer Biology