EGFR inhibition in lung adenocarcinoma upregulates cell surface expression of the placental antigen ALPP and enhances efficacy of ALPP-ADC therapy
y. chen, M. J. Hong, H. Xu, J. Vykoukal, S. Park, y. Cai, R. A. Leon-Letelier, E. Irajizad, F. C. Hsiao, J. B. Dennison, E. J. Ostrin, J. F. Fahrmann, H. Katayama, S. M. Hanash
The paper shows EGFR inhibition increases ALPP surface expression in lung adenocarcinoma, enhancing the effectiveness of ALPP-ADC therapy.
bioRxiv · Mar 27, 2023 · PreprintCancer Biology