L. Ly

De novo antibody discovery in human blood from full-length single B cell transcriptomics and matching haplotyped-resolved germline assemblies

This study uses single-cell transcriptomics and germline haplotype assembly to discover antibodies from human blood post-MMR vaccination, showing neutralization of measles virus.

Giant genes are rare but implicated in cell wall degradation by predatory bacteria

The paper identifies giant genes in predatory bacteria, showing they are associated with prey adhesion and cell wall degradation.

Asgard archaea modulate potential methanogenesis substrates in wetland soil

The paper reconstructs genomes of soil-associated Asgard archaea and uses metatranscriptomics to show their role in carbon compound metabolism relevant to methane production in wetlands.

Borg extrachromosomal elements of methane-oxidizing archaea have conserved and expressed genetic repertoires

The paper identifies conserved genetic repertoires in Borg extrachromosomal elements of methane-oxidizing archaea and shows their higher expression than host genes.

Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes

This paper identifies novel enzymes from gut Firmicutes that convert 'kinked' primary bile acids into 'flat' secondary bile acids, with increased abundance in colorectal cancer patients.

Infection with novel Bacteroides phage BV01 alters host transcriptome and bile acid metabolism in a common human gut microbe

This paper shows that infection with Bacteroides phage BV01 alters host transcriptome and bile acid metabolism in B. vulgatus, with effects dependent on tspO gene disruption.

Pro-Resolving Mediator Profiles And 5-Lipoxygenase Activity In Cerebrospinal Fluid Correlate with Disease Severity and Outcome in Adults with Tuberculous Meningitis

This study identifies CSF pro-resolving mediator profiles and 5-lipoxygenase activity as correlates of disease severity and 80-day survival in adults with tuberculous meningitis.