Author

H. McClafferty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

N. Romano· 2 shared A. Fidanza· 1 shared A. M. Evans· 1 shared A. May· 1 shared B. R. Walker· 1 shared B. Viollet· 1 shared F. P. Luongo· 1 shared H. A. Taylor· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

N. Romano

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A novel human pluripotent stem cell-based gene activation system identifies IGFBP2 as a mediator in the production of hematopoietic progenitors in vitro

P. Petazzi, T. Ventura, F. P. Luongo, H. McClafferty, A. May, H. A. Taylor, M. Shipston, N. Romano, L. Forrester, P. Menendez, A. Fidanza

This paper introduces an iCRISPRa system to activate transcription factors in iPSCs, identifying IGFBP2 as critical for hematopoietic progenitor production.

bioRxiv · Jan 14, 2024 · PreprintCell Biology

AMPK deficiency in smooth muscles causes persistent pulmonary hypertension after birth and premature death

J. Moral-Sanz, S. A. Lewis, S. MacMillan, M. Meloni, H. McClafferty, B. Viollet, M. Foretz, J. del-Pozo, A. M. Evans

This study shows that AMPK-1/2 deficiency in smooth muscles leads to persistent pulmonary hypertension and premature death in mice, with no systemic vasculopathy.

bioRxiv · Jun 8, 2022 · PreprintPathology

Dissection of the corticotroph transcriptome in a mouse model of glucocorticoid-induced suppression of the HPA axis

N. Romano, P. Duncan, H. McClafferty, O. Nolan, Q. Ding, N. Z. Homer, P. Le Tissier, B. R. Walker, M. J. Shipston, T. J. G. Chambers

This study examines the effects of DEX treatment on the corticotroph transcriptome in mice, finding persistent changes in gene expression 4 weeks after treatment withdrawal.

bioRxiv · Jul 29, 2020 · PreprintPhysiology