A. May

Quantifying evidence for phenotypic specificity (PP4) for syndromic phenotypes: Large-scale integration of rare germline FH variants from diagnostic laboratory testing for HLRCC (Hereditary Leiomyomatosis and Renal Cell Cancer) and renal cancer

The paper quantifies phenotypic specificity of rare FH variants in HLRCC and renal cancer using likelihood ratios from clinical and population data.

A novel human pluripotent stem cell-based gene activation system identifies IGFBP2 as a mediator in the production of hematopoietic progenitors in vitro

This paper introduces an iCRISPRa system to activate transcription factors in iPSCs, identifying IGFBP2 as critical for hematopoietic progenitor production.

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

Modelling the Erythroblastic Island Niche of Dyserythropoietic Anaemia Type IV patients using Induced Pluripotent Stem Cells

This study uses iPSCs to model CDA type IV, showing KLF1-E325K mutations impair erythroid cell production and slightly affect macrophage maturation in the EBI niche.

Genetic elements orchestrating Lactobacillus crispatus glycogen metabolism in the vagina

This study identifies genetic variation and regulation of the pulA gene in Lactobacillus crispatus, showing its role in glycogen metabolism and its presence in vaginal microbial communities.

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike

This study determines cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike and compares them to BA.1, revealing structural changes and immune evasion mechanisms.

Structural diversity of the SARS-CoV-2 Omicron spike

The paper compares cryo-EM structures of SARS-CoV-2 Omicron and Delta spikes to analyze conformational changes affecting immune evasion and transmissibility.

Wnt/β-catenin regulates alloreactive T cells for the treatment of hematological malignancies

This study shows that β-catenin regulates donor T cells in allo-HSCT, reducing GVHD while preserving GVL effects through altered cytokine production and cytotoxicity.

TCF-1 in CD4 T cells regulates GVHD severity and persistence

This study shows that loss of TCF-1 in mature CD4 T cells reduces GVHD severity and persistence by impairing T cell function and increasing exhaustion.