Q. Ding

TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry

This paper identifies TRIM32 as an intrinsic restriction factor against alphavirus infection, showing it inhibits viral genome translation through monoubiquitination and that disease mutants lose this antiviral activity.

The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish

The study shows that the intestinal microbiome, specifically Cetobacterium somerae, inhibits viral infection in zebrafish via a TLR2-type I IFN signaling pathway.

Engineered Migrasomes: Harnessing Core Migrasome Machinery and Hypotonic Shock to Develop a Robust and Thermally Stable Vaccine Platform

This study engineers migrasome-like vesicles (eMigrasomes) using hypotonic shock to create a stable, thermally robust vaccine platform that elicits strong immune responses.

Deciphering the gut microbiome of grass carp through multi-omics approach

The paper uses a multi-omics approach to analyze the gut microbiome of grass carp, identifying two functional groups and proposing a biomarker for microbiota structure and function.

CaCO3 Nanoparticles Delivering MicroRNA-200c Suppress Oral Squamous Cell Carcinoma

This study evaluates CaCO3-based nanoparticles delivering miR-200c to suppress OSCC growth and metastasis in vitro and in vivo.

RORγt+ B cells express proinflammatory cytokines and promote allo- and auto- immunity

The paper identifies TIM-4+ B cells that express proinflammatory cytokines like IL-17A and promote auto- and allo-immunity by preventing their conversion into regulatory B cells.

A Medium Chain Fatty Acid, 6-hydroxyhexanoic acid (6-HHA), Protects Against Obesity and Insulin Resistance

This paper identifies 6-hydroxyhexanoic acid (6-HHA), a medium chain fatty acid from Streptococcus gordonii, as a compound that reduces obesity and insulin resistance in mice fed a high-fat diet.

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication

This study identifies the role of G3BP1-N interaction in SARS-CoV-2 replication by showing that disrupting this interaction reduces viral replication and pathogenesis.

Prion-like characteristics of Hepatitis E virus ORF3 protein are associated with virus release and pathogenesis

This study identifies HEV-ORF3 as a prion-like protein that facilitates virion release and pathogenesis by forming filamentous structures, highlighting its role in viral assembly.

Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

The evolution of the human DNA replication timing program

This study examines replication timing evolution across humans, chimpanzees, and rhesus macaques, finding sequence-driven changes that impact gene regulation and chromatin structure.

Vitamin C is an efficient natural product for prevention of SARS-CoV-2 infection by targeting ACE2 in both cell and in vivo mouse models

This paper shows that Vitamin C reduces ACE2 protein levels and blocks SARS-CoV-2 infection in cell and mouse models by inhibiting USP50-ACE2 interaction.

Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

Phosphoantigens are Molecular Glues that Promote Butyrophilin 3A1/2A1 Association Leading to Vγ9Vδ2 T Cell Activation

The paper shows phosphoantigens glue BTN3A1 and BTN2A1 together, initiating gamma-delta T cell activation through intracellular signaling.

An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants

This paper develops a biparatopic nanobody with broad neutralization against multiple SARS-CoV-2 variants, including Omicron, showing strong affinity and activity.

Inhibition of SAR S-CoV-2 infection and replication by lactoferrin, MUC1 and α-lactalbumin identified in human breastmilk

This study identifies lactoferrin, MUC1, and α-lactalbumin in human breastmilk as antiviral components that inhibit SARS-CoV-2 infection and replication, including variants.

Characterization of SARS-CoV-2 variants B.1.617.1 (Kappa), B.1.617.2 (Delta) and B.1.618 on cell entry, host range, and sensitivity to convalescent plasma and ACE2 decoy receptor

This study characterizes SARS-CoV-2 variants Kappa, Delta, and B.1.618, finding increased ACE2 binding in non-human hosts, enhanced spike cleavage, and reduced neutralization sensitivity, but maintained sensitivity to ACE2 decoy receptor.

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

This study identifies the Y453F mutation in SARS-CoV-2 spike protein as enhancing binding to mink ACE2 while maintaining human ACE2 utilization, highlighting its role in host adaptation.

Susceptibilities of human ACE2 genetic variants in coronavirus infection

The paper investigates how genetic variants in the ACE2 gene affect susceptibility to SARS-CoV-2 infection by analyzing their impact on viral entry.

LENG8 regulation of mRNA processing, is responsible for the control of mitochondrial activity

This study identifies LENG8 as an mRNA processing factor that regulates mitochondrial activity by controlling mRNA nuclear export and mitochondrial protein expression.

Analysis of viral RNA-host protein interactomes enables rapid antiviral drug discovery

The paper identifies antiviral drugs by analyzing RNA-host protein interactomes of SARS-CoV-2, EBOV, and ZIKV.

SARS-CoV-2 variants resist antibody neutralization and broaden host ACE2 usage

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis

This study identifies an EMT-primary cilium-GLIS2 signaling axis that regulates mammary stem cell properties and claudin-low breast tumorigenesis.

A novel cell culture system modeling the SARS-CoV-2 life cycle

This paper develops a BSL-2 cell culture system for producing SARS-CoV-2 virus-like particles to enable safe antiviral screening and life cycle studies.

Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimers disease brain

This study shows that ACE2 protein is upregulated in Alzheimer's disease brains and correlates with oxidative stress, suggesting a link between Alzheimer's and SARS-CoV-2 receptor expression.

Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry

The paper identifies species-specific genetic differences in ACE2 that determine SARS-CoV-2 entry capability and shows that humanizing these residues in koala and mouse ACE2 enables viral entry.

The S1/S2 boundary of SARS-CoV-2 spike protein modulates cell entry pathways and transmission

This study shows that the S1/S2 boundary of the SARS-CoV-2 spike protein affects cell entry and transmission by altering the pathway used for viral entry.

Dietary propionate induces intestinal oxidative stress via inhibition of SIRT3-mediated SOD2 depropionylation

This study shows dietary propionate causes intestinal oxidative stress in zebrafish by inhibiting SIRT3-mediated SOD2 depropionylation, leading to gut microbiota changes.

Dissection of the corticotroph transcriptome in a mouse model of glucocorticoid-induced suppression of the HPA axis

This study examines the effects of DEX treatment on the corticotroph transcriptome in mice, finding persistent changes in gene expression 4 weeks after treatment withdrawal.

Broad-spectrum virucidal activity of bacterial secreted lipases against flaviviruses, SARS-CoV-2 and other enveloped viruses

This study identifies two bacterial lipases with broad-spectrum antiviral activity against multiple enveloped viruses, including SARS-CoV-2, by disrupting viral envelopes.