M. Meloni

Structural and functional characterization of chloroplast ribulose-5-phosphate-3-epimerase from the model green microalga Chlamydomonas reinhardtii

This study characterizes the structural and functional properties of CrRPE1, an enzyme in the Calvin-Benson-Bassham cycle of Chlamydomonas reinhardtii, revealing its catalytic behavior and regulatory mechanisms.

AMPK deficiency in smooth muscles causes persistent pulmonary hypertension after birth and premature death

This study shows that AMPK-1/2 deficiency in smooth muscles leads to persistent pulmonary hypertension and premature death in mice, with no systemic vasculopathy.

Structural snapshots of nitrosoglutathione binding and reactivity underlying S-nitrosylation of photosynthetic GAPDH

This study investigates how GSNO induces S-nitrosylation of CrGAPA, revealing structural and mechanistic insights into its redox specificity and enzyme inactivation.

Contractile reprogramming of cardiac pericytes by MEK inhibition promotes arteriologenesis of the ischemic heart

This study shows that MEK inhibition reprograms cardiac pericytes into contractile cells, promoting arteriologenesis in ischemic hearts.

Structural and functional insights into nitrosoglutathione reductase from Chlamydomonas reinhardtii

The paper characterizes CrGSNOR1 from Chlamydomonas reinhardtii, revealing its strict specificity for GSNO and NADH, conserved 3D structure, and resistance to thiol-based redox modifications.

The pericardium promotes cardiac repair and remodelling post-myocardial infarction

This study shows that the pericardium promotes cardiac repair and reduces mortality after myocardial infarction by regulating inflammation and macrophage polarization.

Eosinophil deficiency promotes aberrant repair and adverse remodelling following acute myocardial infarction

This study shows that eosinophil deficiency after myocardial infarction leads to adverse cardiac remodeling, which can be mitigated by IL-4 therapy.

Evidences of a cytotoxic activity of S-adenosylmethionine on OCI-AML3 cells

This paper investigates the cytotoxic effect of S-adenosylmethionine (SAM) on OCI-AML3 cells and finds it induces cell death without significant apoptosis at concentrations achievable in humans.