Author

H. Morgan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Immunology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Gomez-Marin· 1 shared A. J. Warren· 1 shared A. Ostmann· 1 shared A. Ziady· 1 shared B. Carey· 1 shared B. D. Bax· 1 shared B. Trapnell· 1 shared C. Chabbert· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperScientific Communication & Education

A. Gomez-Marin

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4 papers

Recent·Most cited

A 2.8A structure of zoliflodacin in a DNA-cleavage complex with Staphylococcus aureus DNA gyrase

H. Morgan, M. Lipka-Lloyd, A. J. Warren, N. Hughes, J. Holmes, N. P. Burton, E. Mahenthiralingam, B. D. Bax

This paper reports the 2.8Å X-ray structure of zoliflodacin bound to Staphylococcus aureus DNA gyrase, showing its mechanism of DNA cleavage inhibition and improved antibacterial activity.

bioRxiv · Nov 30, 2022 · PreprintBiophysics

Alpha-1 Antitrypsin Limits Neutrophil Extracellular Trap Disruption of Airway Epithelial Barrier Function

K. M. Hudock, M. S. Collins, M. A. Imbrogno, J. J. Brewington, A. Ziady, N. Zhang, J. M. Snowball, Y. Xu, B. Carey, Y. Horio, S. O'Grady, E. Kopras, J. Meeker, H. Morgan, A. Ostmann, , J. P. Clancy

This study shows that neutrophil extracellular traps (NETs) disrupt airway epithelial barrier function by causing cell death and E-cadherin degradation, which can be mitigated by alpha-1 antitrypsin.

bioRxiv · Mar 18, 2022 · PreprintImmunology

Generation and characterisation of an estrogen receptor-positive GEMM-derived Pten p53 null transplantable breast tumour model for therapeutic testing

E. J. Davies, H. Morgan, G. Tornillo, C. Chabbert, H. Kendrick, M. J. Ahdesmaki, S. Luke, S. T. Barry, M. J. Smalley

The paper develops a transplantable breast tumour model from an ER+ GEMM to study therapeutic resistance and pathway dependencies in breast cancer.

bioRxiv · Sep 12, 2019 · PreprintCancer Biology

Reproducibility and replicability of rodent phenotyping in preclinical studies

N. Kafkafi, J. Agassi, E. J. Chesler, J. C. Crabbe, W. E. Crusio, D. Eilam, R. Gerlai, I. Golani, A. Gomez-Marin, R. Heller, F. Iraqi, I. Jaljuli, N. A. Karp, H. Morgan, G. Nicholson, , Y. Benjamini

The paper discusses concerns about reproducibility and replicability in rodent phenotyping studies and emphasizes the need for improved data sharing and community efforts to address methodological issues.

Neuroscience & Biobehavioral Reviews · Apr 1, 2018Peer-reviewedScientific Communication & Education