Author

Y. David

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:chromatin & epigenetic regulation· 5 Assay:proteomics· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

A. Osunsade· 3 shared M. Schuldiner· 2 shared R. Valenti· 2 shared S. Liu· 2 shared A. Agustinus· 1 shared A. Al-Kachak· 1 shared A. Cadou· 1 shared A. Fadel· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersBiophysics

A. Osunsade

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

A proteome-wide yeast degron collection for the dynamic study of protein function.

R. Valenti, Y. David, D. Edilbi, B. Dubreuil, Y. Asraf, T. Meir-Salame, E. Sass, M. Schuldiner

The paper introduces an AID library for on-demand protein depletion in yeast, enabling systematic study of protein function and uncovering new roles in cell cycle and mitochondrial processes.

bioRxiv · Jun 10, 2024 · PreprintCell Biology

Flexible and site-specific manipulation of histones in live animals

E. Finkin-Groner, A. Al-Kachak, A. S. Agustinus, R. Bastle, A. Lepack, Y. Lyu, I. Maze, Y. David

This paper introduces a method for site-specific histone manipulation in live animals, demonstrating its application in rodent neurons to study chromatin dynamics.

bioRxiv · Mar 19, 2023 · PreprintBiochemistry

Chromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA

T. Nguyen, S. Li, J. Chang, J. Watters, H. Ng, A. Osunsade, Y. David, S. Liu

This study shows that Sox2 forms DNA condensates that exert mechanical forces up to 7 pN, but chromatin nucleosomes reduce this force by sequestering Sox2.

bioRxiv · Feb 2, 2022Biophysics

Epigenetic dysregulation from chromosomal transit in micronuclei

A. Agustinus, R. Raviram, B. Dameracharla, J. Luebeck, S. Stransky, L. Scipioni, R. Myers, M. DiBona, M. Duran, B. Weigelt, S. Yomtoubian, E. Toufektchan, P. Mischel, V. Mittal, S. Shah, , S. F. Bakhoum

This study shows that chromosomal transit through micronuclei causes epigenetic dysregulation in cancer cells, leading to long-term chromatin accessibility abnormalities.

bioRxiv · Jan 12, 2022Cancer Biology

Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution

I. G. Castro, S. P. Shortill, S. K. Dziurdzik, A. Cadou, S. Ganesan, E. J. Fenech, H. Meyer, A. Fadel, Y. David, M. Davey, C. Mattes, R. Valenti, R. Ernst, V. Zaremberg, T. P. Levine, , M. Schuldiner

The paper systematically analyzes membrane contact sites in yeast to identify new proteins involved in lipid distribution.

bioRxiv · Oct 17, 2021Cell Biology

Single-stranded nucleic acid sensing and coacervation by linker histone H1

R. Leicher, A. Osunsade, A. Latham, G. N. L. Chua, J. W. Watters, S. Christodoulou-Rubalcava, B. Zhang, Y. David, S. Liu

This study investigates how linker histone H1 interacts with single-stranded DNA, revealing coacervation and phase separation mechanisms.

bioRxiv · Mar 17, 2021Biophysics

Protein Arginine Deiminase 4 Antagonizes Methylglyoxal-induced Histone Glycation

Q. Zheng, A. Osunsade, Y. David

This study shows PAD4 counteracts MGO-induced histone glycation by converting arginines to citrulline and removing glycation adducts, linking PAD4 to cancer progression.

bioRxiv · Oct 31, 2019Biochemistry