Cancer BiologybioRxivPreprint
Synthetic lethality targeting LKB1 mutant and EGFR wild type human non-small cell lung cancer cells by glucose starvation and SGLT2 inhibition
Y. Ren, J. Chen, X. Mo…·H.-M. Shen
This study identifies glucose starvation and SGLT2 inhibition as synthetic lethal strategies for EGFR-WT/LKB1-mutant NSCLC, showing efficacy in xenograft models.
DOI 10.1101/622126