X. Mo

An axonemal intron splicing program sustains Plasmodium male development

This study identifies RBPm1 as a splicing activator essential for axoneme assembly in Plasmodium male gametogenesis, revealing an intron splicing program critical for male development.

A multiplexed time-resolved fluorescence resonance energy transfer ultrahigh-throughput screening assay for targeting SMAD4-SMAD3-DNA complex

This paper develops a multiplexed TR-FRET assay to screen small molecule inhibitors targeting the SMAD4-SMAD3-DNA complex, identifying gambogic acid and gambogenic acid as potential hits.

Dysregulated expression of Hoxa1 isoforms in hematopoietic stem and progenitor cells causes myelodysplastic syndromes.

This study shows that dysregulated Hoxa1 isoforms in hematopoietic stem and progenitor cells cause myelodysplastic syndromes and provide mouse models for disease progression.

EB1 decoration of microtubule lattice facilitates spindle-kinetochore lateral attachment in Plasmodium male gametogenesis

This study identifies Plasmodium EB1's unique MT-lattice binding role in facilitating spindle-kinetochore lateral attachment during male gametogenesis, essential for proper chromosome segregation and parasite transmission.

Heat dissipation from photosynthesis contributes to maize thermoregulation under suboptimal temperature conditions

This study investigates how maize thermoregulates by dissipating heat from photosynthesis, showing that non-photochemical quenching (NPQ) helps maintain optimal leaf temperatures under suboptimal conditions.

Mechanistic basis for targeting homologous recombination defective liver cancer via synthetic lethality

This study identifies a novel subtype of HRD in HBVHCC caused by CDW19S perturbation and shows it can be targeted therapeutically.

Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel

This study shows that tyrosine phosphorylation modulates TRPV2's chemical and thermal sensitivity in macrophages through JAK1 and PTPN1.

Interferon-Gamma Signaling Promotes Melanoma Progression and Metastasis

This study shows that IFNG signaling promotes melanoma progression and metastasis by modulating the tumor microenvironment through Stat1 and γδ T cells.

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

The paper identifies mutation-directed neo-protein-protein interactions in cancer using a high-throughput screening platform, revealing therapeutic opportunities through neo-interaction rewiring.

Pharmacological rescue of tumor intrinsic STING expression and immune response in LKB1-mutant lung cancer via the IAP-JAK regulatory axis

The paper identifies IAP inhibitors as sensitizers that restore immune response in LKB1-mutant lung cancer by reactivating the STING pathway and enhancing immune infiltration.

brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury

This study examines how BRCA2 mutations affect zebrafish development and injury response, revealing context- and tissue-dependent cellular changes in embryos and adults.

Survival mechanism of a novel marine multistress-tolerant Meyerozyma guilliermondii GXDK6 under high NaCl stress as revealed by integrative omics analysis

This study identifies the survival mechanism of Meyerozyma guilliermondii GXDK6 under high NaCl stress using integrative omics analysis, revealing key genes and pathways involved in salt tolerance.

Structural insights into the recognition of histone H3Q5 serotonylation by WDR5

This study identifies WDR5 as a reader of H3Q5ser, showing it binds to this modification and promotes transcription in neuroblastoma cells, suggesting a role in tumorigenesis.

Unravelling processes between phenotypic plasticity and population dynamics in migratory birds

This study investigates how the loss of staging habitats affects migration strategies and population dynamics in migratory birds through phenotypic plasticity.

Synthetic lethality targeting LKB1 mutant and EGFR wild type human non-small cell lung cancer cells by glucose starvation and SGLT2 inhibition

This study identifies glucose starvation and SGLT2 inhibition as synthetic lethal strategies for EGFR-WT/LKB1-mutant NSCLC, showing efficacy in xenograft models.