BiochemistrybioRxiv
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
S. V. Faull, A. Lau, C. Martens…·A. Politis
The paper determines the structure and dynamics of CSN-CRL2 complexes using cryo-EM and mass spectrometry, revealing a stepwise activation mechanism.
DOI 10.1038/s41467-019-11772-y