MicrobiologybioRxiv
Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance
H. Safi, P. Gopal, S. Lingaraju…·D. Alland
This paper identifies a novel mechanism of drug tolerance in M. tuberculosis through phase variation in the glpK gene, showing reversible frameshift mutations that contribute to treatment failure and relapse.
DOI 10.1073/pnas.1907631116