M. Hoque

Structural characterization of two full length γδTCR/CD3 complexes

This study reports cryoEM structures of two full-length γδ TCR/CD3 complexes, revealing similarities to β TCRs but with highly mobile extracellular domains and a dimeric assembly in one complex.

Genotypic variation in resource exchange, use, and production traits in the legume-rhizobia mutualism

This study quantifies how host and symbiont genotypes influence resource exchange, use, and production traits in legume-rhizobia mutualisms, finding that rhizobia genotype and GxG effects are common for exchange traits but not for use and production traits.

A Soluble Platelet-Derived Growth Factor Receptor-β Originates via Pre-mRNA Splicing in the Healthy Brain and is Differentially Regulated during Hypoxia and Aging

This study identifies soluble PDGFRβ isoforms generated by pre-mRNA splicing in the healthy brain, showing increased levels with age and hypoxia.

Bone Marrow-Derived Cells Contribute to the Maintenance of Thymic Stroma including Thymic Epithelial Cells

The paper identifies BM-derived CD45+EpCAM+ cells that contribute to thymic stroma and TEC maintenance, challenging the notion that these cells originate solely from endoderm.

The PRR14 heterochromatin tether encodes modular domains that mediate and regulate nuclear lamina targeting

This study identifies a modular nuclear lamina binding domain in PRR14 that mediates heterochromatin anchoring and is regulated by phosphorylation and a PP2A phosphatase site.

Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance

This paper identifies a novel mechanism of drug tolerance in M. tuberculosis through phase variation in the glpK gene, showing reversible frameshift mutations that contribute to treatment failure and relapse.